American ginseng's effects on urine and blood metabolites
LCMS-Based Metabolic Analysis Explores the Effect of American Ginseng on Urine and Plasma in Healthy Individuals
This test will see if taking 3 grams of American ginseng daily for 14 days changes metabolites in urine and blood in healthy adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Zhejiang Cancer Hospital Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT07252362 on ClinicalTrials.gov |
What this trial studies
Researchers will give healthy adults 3 grams of American ginseng powder daily for 14 days and use LC‑MS metabolomic analysis to profile changes in urine and plasma. Fasting urine samples will be collected at baseline, day 7, and day 14, and fasting serum samples at baseline and day 14 at Zhejiang Cancer Hospital. Participants will follow a light diet, avoid alcohol and caffeine, and be monitored for any adverse effects throughout the study. The trial enrolls healthy volunteers aged 18 to 45 with no significant medical history or drug allergies.
Who should consider this trial
Good fit: Healthy adults aged 18–45 with no major medical history, normal routine physical exam results, no known drug allergies, and willingness to follow dietary restrictions and attend fasting sample visits.
Not a fit: People with chronic illnesses, current medication use, known drug allergies, or those outside the 18–45 age range are unlikely to benefit or qualify for this protocol.
Why it matters
Potential benefit: If successful, this could reveal how American ginseng alters metabolism and identify biomarkers to guide safe use or future therapeutic research.
How similar studies have performed: Previous metabolomics studies of botanical supplements and some work on American ginseng have shown metabolic changes, but LC‑MS profiling in healthy volunteers for this specific question is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
* 18 to 45 years old; * The subjects were fully informed about the research process and signed the informed consent form (the subjects had no abnormalities in routine physical examinations, no previous medical history, and no history of drug allergies); ③ During the trial, they were required to have a light diet and were prohibited from consuming alcoholic and caffeinated beverages;
Where this trial is running
Hangzhou, Zhejiang
- Zhejiang Cancer Hospital — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: guan ai Bao, Master
- Email: doctorbga@126.com
- Phone: +8615968857341
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.