Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment for Gingivitis
Official title: Effect of Alpha-Lipoic Acid Supplementation as an Adjunct to Non-Surgical Periodontal Treatment on Biomarker Levels in Individuals With Gingivitis
Run by Biruni University · NCT07882394 · Data updated 2026-11-12
This study tests whether adding alpha-lipoic acid to standard non-surgical gum treatment can help people with gingivitis see improved biomarkers and symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Biruni University Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | August 5, 2026 |
| Main results expected | May 5, 2027 |
| Study ends | August 5, 2027 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT07882394 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-65 who are systemically healthy, have at least 20 natural teeth, and have not had periodontal treatment in the past 6 months.
✕Probably not a fit
Individuals who do not experience a reduction in inflammatory markers or whose baseline conditions are not influenced by antioxidant therapy may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this study, adults with gingivitis receive standard non-surgical periodontal care with or without alpha-lipoic acid at 200 mg or 600 mg. The trial will measure inflammatory and oxidative stress biomarkers such as 8-OHdG, MDA, TAC, and CRP to see if the supplement enhances the response to treatment. Effects on clinical markers of gingival inflammation will also be monitored. The trial is conducted at Biruni University in Istanbul, with participants screened for health criteria and safety considerations. The design compares placebo, low-dose, and high-dose alpha-lipoic acid as an adjunct to conventional care.
Why it matters
Potential benefit: If successful, alpha-lipoic acid could improve the effectiveness of gum treatment and reduce oxidative stress related to gingivitis.
How similar studies have gone: Previous research has explored antioxidants in periodontal care, with some showing potential benefits, making this approach promising but still exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Aged 18-65 years Systemically healthy Having ≥20 natural teeth No periodontal treatment within the previous 6 months No use of antibiotics or non-steroidal anti-inflammatory drugs (NSAIDs) within the previous 3 months Non-smokers Willing to participate voluntarily and provide informed consent Exclusion Criteria: Use of immunosuppressive medications or corticosteroids Pregnancy or lactation Current orthodontic treatment Excessive alcohol consumption or substance abuse Non-compliance with the study protocol or treatment requirements
Where it's running
-
Biruni University
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Burcu Karaduman, PhD
- Email: bkaraduman@gmail.com
- Phone: +90 444 8 276
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.