Allopurinol for Depression in Adults on Sertraline

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and effectiveness of combining allopurinol with sertraline in adults with major depressive disorder. Participants will receive sertraline 50 mg plus allopurinol 300 mg and will be monitored for changes in depressive symptoms and tolerability. The trial includes adults with a HAM-D score of 10 or higher and excludes those with bipolar disorder, eating disorders, pregnancy, cardiovascular issues, or severe kidney problems. It is conducted at Tanta University under a non-commercial collaboration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients aged greater than 18 years old. Patients with a HAM-D score of at least 10 with item 1, depressed mood, scoring 2 or greater, are eligible.

Exclusion Criteria:

Patients with bipolar I or bipolar II disorder Patients with eating disorders Pregnant women or women not using medically accepted means of birth control Cardiovascular disorders Severe renal impairment

Where it's running

• Tanta Unuversity
  Tanta, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.