AI-assisted detection and diagnosis of sessile serrated lesions during colonoscopy
Official title: USAGE OF ARITIFICIAL INTELLIGENCE IN AIDING WITH COLONIC SESSILE SERRATED LESIONS DETECTION AND DIAGNOSIS (AI-SSLD)
Run by National Healthcare Group, Singapore · NCT07650344 · Data updated 2026-11-12
A real-time AI detection tool is being tested to see if it helps find sessile serrated lesions during colonoscopy more often than standard white-light exams.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 80 Years |
| Sex | All |
| Enrollment | 628 (estimated) |
| Sponsor | National Healthcare Group, Singapore Government |
| Locations | 3 sites (Singapore and 2 other locations) |
| Status | Recruiting |
| Started | May 21, 2026 |
| Main results expected | May 2027 |
| Study ends | May 3, 2027 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT07650344 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 40–80 years old undergoing colonoscopy for screening, surveillance, or diagnostic indications with adequate bowel prep and consent.
✕Probably not a fit
Patients with poor bowel prep, incomplete colonoscopy, or contraindications to colonoscopy may not benefit and could be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates a computer-aided detection (CADe) system used in real time during colonoscopy to improve SSL detection compared with conventional white-light endoscopy. SSLs are linked to a portion of colorectal cancer and can be challenging to detect, contributing to variability in diagnosis among clinicians. The trial includes adults aged 40–80 undergoing colonoscopy for screening, surveillance, or diagnostic purposes, with adequate bowel preparation and consent. Participants will undergo colonoscopy with the CADe system, and outcomes will be compared to standard practice. The objective is to determine whether CADe increases SSL detection rates and potentially informs subsequent management.
Why it matters
Potential benefit: If successful, CADe could lead to higher SSL detection, enabling earlier removal and potentially reducing colorectal cancer risk.
How similar studies have gone: Prior studies of CADe in colonoscopy have shown promise in improving polyp detection, but SSL-focused data are still emerging.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult (40 - 80 years) Undergoing colonoscopy for screening, surveillance, or diagnostic indications. Complete colonoscopy with satisfactory Boston Bowel Prep Scale of 6 or higher. Provide informed consent to participate in the study Exclusion Criteria: Personal or family history of colorectal cancer Personal or family history of colonic polyposis syndromes Personal or family history of inflammatory bowel disease Prior colorectal surgery Contraindications to colonoscopy (intestinal obstruction, medical conditions that will make the risk of colonoscopy too high) Contraindications to polypectomy (ongoing anticoagulation / double antiplatelet therapy that cannot be stopped for the colonoscopy) Inability to give consent Incomplete colonoscopy/ Unable to retrieve specimen for pathology Poor bowel preparation (Boston Bowel Prep Scale \<6) Pregnant Women
Where it's running
-
Tan Tock Seng Hospital
Singapore, Singapore Recruiting -
National University of Singapore
Singapore, Singapore Recruiting -
Changi General Hospital
Singapore, Singapore Not yet recruiting
Study contacts
- Study coordinator: Weida Chew, Masters
- Email: wei.da.chew@nhghealth.com.sg
- Phone: 63577897
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Water-exchange colonoscopy with AI detection, with or without linked-color imaging, to find serrated colon lesions
This trial tests whether adding linked-color imaging to water-exchange colonoscopy with AI-assisted detection helps doctors find clinically significant serrated lesions in people aged 40–80 having colonoscopy for screening, surveillance, symptoms, or a positive stool test.
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A new technique for removing colonic polyps
This study tests a new method for removing colon polyps to see if it helps doctors get rid of them more completely and reduce the chances of them coming back.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.