A new technique for removing colonic polyps
Official title: The Cap-Assisted Resection Margin Assessment (CARMA) Technique After Polyp Resection: a Prospective Feasibility Study of a "Novel" Approach to Reduce Polyp Recurrence
Run by Princess Alexandra Hospital, Brisbane, Australia · NCT05099432 · Data updated 2026-11-12
This study tests a new method for removing colon polyps to see if it helps doctors get rid of them more completely and reduce the chances of them coming back.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Princess Alexandra Hospital, Brisbane, Australia Academic / other |
| Locations | 1 site (Woolloongabba, Queensland) |
| Status | Recruiting |
| Started | November 2021 |
| Main results expected | May 2023 |
| Study ends | November 2026 |
| Registry record updated | November 15, 2021 |
| Trial ID | NCT05099432 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with colonic polyps who require polypectomy.
✕Probably not a fit
Patients with small polyps under 10mm or those with specific exclusion criteria such as pedunculated polyps or evidence of invasion may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the Cap Assisted Resection Margin Assessment (CARMA) technique, which aims to improve the removal of colonic polyps by ensuring a clear margin during endoscopic procedures. The technique utilizes high-definition video endoscopes with advanced imaging features to standardize the assessment of resection margins after polypectomy. By addressing the issue of incomplete polyp resection, the CARMA technique seeks to reduce polyp recurrence rates and the associated risk of interval cancers.
Why it matters
Potential benefit: If successful, this technique could significantly lower the rates of colorectal cancer by ensuring more complete removal of polyps.
How similar studies have gone: While the CARMA technique is a novel approach, similar studies focusing on improved polyp resection techniques have shown promise in enhancing outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Patients with colonic polyps will be considered following below criteria Inclusion Criteria: \- any polypectomy (though only a maximum of two polyps from one individual participant) Exclusion Criteria: * polyps less than 10mm which were resected under endoscopic view with a definite \> 1mm clear margin * scar site recurrence polyps * polyps with endoscopic evidence of invasion * pedunculated polyps * pseudopolyps * participants who will not be available for follow up endoscopy
Where it's running
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Princess Alexandra Hospital
Woolloongabba, Queensland, Australia Recruiting
Study contacts
- Principal investigator: Alexander Huelsen, MD — Princess Alexandra Hospital
- Study coordinator: Alexander Huelsen, MD
- Email: alexander.huelsenkatz@health.qld.gov.au
- Phone: +61 7 3176 2111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.