Aerobic cycling versus therapeutic exercise for knee osteoarthritis pain sensitivity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Ninety adults with symptomatic knee osteoarthritis will be randomized to one of two exercise programs delivered three times per week for ten weeks: aerobic exercise on a recumbent cycle ergometer with effort guided by the Borg scale, or a multi-component therapeutic program including resistance, neuromuscular, mobility, and balance exercises. The primary outcome is exercise-induced hypoalgesia, measured as within-session increases in pressure pain threshold at the knee across four anchor sessions during the 10-week program. Allocation will be concealed with opaque envelopes and the outcome assessor will be blinded to group assignment. Baseline and 10-week assessments will be performed to compare changes between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of symptomatic knee osteoarthritis for at least 3 months.
* Report of knee pain for more than 3 months and average knee pain intensity ≥ 3 on the 0 to 10 Numeric Rating Scale.
* Morning stiffness lasting less than 30 minutes.
* Clinical signs compatible with knee osteoarthritis. crepitus, bony tenderness and absence of palpable warmth at the knee.
* Altered exercise-induced hypoalgesia: absence of exercise-induced hypoalgesia and hyperalgesic response to exercise.

Exclusion Criteria:

* Signs and symptoms indicating the hip as the main source of pain.
* Osteoporosis
* Fibromyalgia
* History of tumors or cancer
* Active inflammatory joint diseases, such as rheumatoid arthritis or gout.
* Previous arthroplasty of any lower limb joint.
* Neurological diseases, including Parkinson's disease, stroke, multiple sclerosis, muscular dystrophy, motor neuron disease or Alzheimer's disease.
* Cardiovascular diseases for which exercise is formally contraindicated.
* Infected wounds or osteomyelitis in the knee region.
* Deep vein thrombosis or thrombophlebitis.
* Sensory alterations in the lower limbs.
* Cognitive or cardiopulmonary impairments that limit safe participation in the exercise program.
* Use of walking aids.
* Recent knee trauma.

Where it's running

• Nove de Julho University
  São Paulo, Brazil Recruiting
• Cid André Fidelis de Paula Gomes
  São Paulo, Brazil Not yet recruiting

Study contacts

• Study coordinator: Cid Gomes, Phd
• Email: cid.andre@gmail.com
• Phone: +5511970941936

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.