Advanced ultrasound imaging for brain blood vessels
Official title: Study of Perforating Arteries Detection by Ultrasound Localization Microscopy (ULM) With a Commercial Conventional Ultrasound Scanner
Run by Assistance Publique - Hôpitaux de Paris · NCT05785598 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing a new ultrasound technique to see if it can help doctors get a clearer picture of small blood vessels in the brains of patients with ischemic stroke and Moya-Moya disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Paris) |
| Trial ID | NCT05785598 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years with ischemic stroke or Moya-Moya disease who have undergone specific imaging procedures.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or not affiliated with French Social Security may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes ultrasound localization microscopy (ULM) to enhance the visualization of small blood vessels in the brain, specifically perforating arteries, in patients with ischemic stroke and Moya-Moya disease. By injecting a contrast agent and processing standard Doppler ultrasound images, the study aims to achieve a tenfold increase in resolution, allowing for better mapping of the microvascular structure. The research will be conducted at Bichat Hospital in Paris, focusing on patients who have undergone routine imaging procedures. The goal is to improve diagnostic capabilities for conditions affecting cerebral blood flow.
Why it matters
Potential benefit: If successful, this technique could lead to improved diagnosis and management of ischemic stroke and Moya-Moya disease by providing clearer images of critical brain blood vessels.
How similar studies have gone: While the use of ultrasound localization microscopy is relatively novel in clinical settings, similar advanced imaging techniques have shown promise in other studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with ischemic stroke hospitalized in the neurology department of the Bichat Hospital in the absence of middle cerebral artery occlusion or lacunar disease. or * Patients followed in the neurology department of the Bichat/Lariboisière hospital with a diagnosis of Moya-Moya disease or syndrome * Patient who has had a TST with contrast injection as part of his follow-up * Patient who has had an MRI as part of his follow-up * Presence of a temporal window that allows ultrasound insonification of the polygon circle of Willis. * Age over 18 years. * Patient not objecting to the analysis of their data Exclusion Criteria: * Patient not affiliated to French Social Security. * Patient under guardianship or curatorship. * Pregnant or breastfeeding patients
Where it's running
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AP-HP, Bichat Hospital
Paris, France Recruiting
Study contacts
- Principal investigator: Elena MESEGUER — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Elena MESEGUER, Doctor
- Email: elena.meseguer@aphp.fr
- Phone: 140257490
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.