Advanced imaging technique for heart blood flow assessment after heart attacks
Diagnostic Performances Assessment of Dynamic 99mTc- Tetrofosmin CZT-SPECT Myocardial Perfusion Imaging in Comparison with Invasive Intra-coronary Fractional Flow Reserve Measurement in Patients with Significant Residual Coronary Artery Stenosis After Acute Coronary Syndrome : Dyna-MI Pilot Study.
This study is testing a new heart imaging technique to see if it can safely and accurately check blood flow in the heart after a heart attack, compared to the traditional method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes) |
| Trial ID | NCT05940285 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of dynamic 99mTc-Tetrofosmin CZT-SPECT myocardial perfusion imaging (MPI) in assessing myocardial flow reserve (MFR) compared to the traditional invasive method of measuring fractional flow reserve (FFR) in patients with significant coronary artery stenosis following acute coronary syndrome. The goal is to validate this non-invasive imaging technique as a reliable alternative for diagnosing coronary artery disease. By comparing the results of the dynamic MPI with invasive FFR measurements, the study aims to provide insights into the diagnostic performance of this advanced imaging method.
Who should consider this trial
Good fit: Ideal candidates include adults with multi-vessel coronary artery disease diagnosed during acute coronary syndrome.
Not a fit: Patients with a history of myocardial infarction or coronary artery bypass surgery, or those with contraindications to the imaging technique, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a safer, non-invasive method for evaluating heart blood flow in patients after heart attacks.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for myocardial perfusion assessment, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient. * Multi vessel coronary arteries disease (at least one non-culprit coronary stenosis \>= 50%) diagnosis during * primary percutaneous coronary intervention \< 12h after ST-elevation myocardial infarction opercutaneous revascularisation of the culprit lesion within 24 to 48 hours of an acute non-ST-segment elevation coronary syndrome. * Written consent. * Social security affiliation Exclusion Criteria: * Non adult patient. * Adult patient under tutelage. * Reproductive age women. * Medical history of myocardial infarction or coronary artery bypass surgery. * Cardiogenic shock. * Cardiomyopathy. * Regadenoson/adenosine/FFR contraindication. * 99mTc-Tetrofosmin hypersensibility. * Small non-culprit coronary arteries. * Participation to another interventional study.
Where this trial is running
Nantes
- Nantes University Hospital — Nantes, France (Recruiting)
Study contacts
- Study coordinator: JAMET Bastien
- Email: Bastien.JAMET@chu-nantes.fr
- Phone: (0)240165521
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.