Adrenogenic Autonomic Cortisol Secretion in Chinese Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort prospectively enrolls Chinese adults with adrenal nodules larger than 10 mm and abnormal dexamethasone suppression to characterize etiology, diagnosis, and prognosis of autonomic cortisol secretion. It aims to develop personalized treatment approaches based on function and diagnostic findings, and to follow patients over time to assess outcomes. The study builds on prior data showing MACS is common and linked to higher risks of metabolic and cardiovascular problems, seeking evidence to standardize care. Imaging advances have increased incidentaloma detection, but prospective data on its management remain limited. No interventions are defined in advance for all participants; treatments are determined as part of routine clinical care guided by study findings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* CT examination revealed adrenal nodules (maximum diameter ≥10mm);
* Serum cortisol \> 50nmol/L after 1mg dexamethasone inhibition test (1mg-DST).

Exclusion Criteria:

* Patients with primary aldosteronism (PA), pheochromocytoma, adrenal metastatic carcinoma, congenital adrenal hyperplasia (CAH), ganglionic neuroma/paraganglioma, schwannoma, adrenal hematoma and those with no definite diagnosis were evaluated by clinical and endocrine function.
* Patients with serious underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamic-pituitary-adrenal axis (HPA axis); Pregnancy.
* Patients with a history of alcoholism, fatigue, trauma, infection, depression, glucocorticoid use, and other drugs affecting the function of the hypothalamic-pituitary-adrenal axis.
* Patients who are not willing to participate in and complete this study refuse to sign the written informed consent for this study.

Where it's running

• Department of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Principal investigator: Qifu Li, PhD — First Affiliated Hospital of Chongqing Medical University
• Study coordinator: Qifu Li, PhD
• Email: liqifu@yeah.net
• Phone: +86-023-89011552

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.