Administering adrenaline in STEMI patients during PCI to prevent no reflow
Official title: Role of Catheter Administered Intracoronary Epinephrine in Prevention of No-Reflow in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention
Run by Ain Shams University · NCT06847568 · Data updated 2026-11-12
This study tests if giving adrenaline during heart procedures can help STEMI patients avoid complications with blood flow without causing heart rhythm problems.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | April 30, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | March 11, 2025 |
| Trial ID | NCT06847568 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older presenting with acute coronary syndrome and diagnosed with STEMI within 12 hours of symptom onset.
✕Probably not a fit
Patients who may not benefit include those under 18, pregnant women, and individuals with contraindications to epinephrine or other serious cardiac conditions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the administration of intracoronary adrenaline in patients with ST Segment Elevation Myocardial Infarction (STEMI) during primary percutaneous coronary intervention (PCI). The study aims to determine if prophylactic use of adrenaline can reduce the incidence of no reflow without increasing the risk of arrhythmias. Patients will receive adrenaline after restoring coronary flow and before stenting, with expert operators performing the procedure. The primary endpoint is the improvement in coronary flow assessed by TIMI flow grading.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the occurrence of no reflow in STEMI patients, improving their outcomes post-PCI.
How similar studies have gone: While the use of adrenaline in this context is being explored, similar studies have shown promise in improving coronary flow, making this approach potentially beneficial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients who are 18 years or older 2. Patients presenting with acute coronary syndrome with ECG criteria diagnostic of STEMI (according to the universal definition of myocardial infarction) within 12 hours from the onset of symptoms and treated by successful primary PCI. Exclusion Criteria: 1. Age \< 18 years 2. Pregnant females. 3. Patients refused to give consent. 4. Patients who had normal coronary angiography. 5. Patients who had CTO lesions. 6. Patients who have SCAD. 7. Patients who developed dissection or mechanical complication during the procedure. 8. Patients presenting with cardiogenic shock. 9. Cardiomyopathies 10. Contraindications to epinephrine as HTN with SBP \>180 mmHg or DBP\>110 mmHg, clinically significant arrhythmia (Atrial fibrillation with rapid ventricular rate, ventricular tachycardia, or ventricular fibrillation) prior to PCI, known allergy to epinephrine.
Where it's running
-
Faculty of medicine Ain Shams Univesity
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Mostafa Abdallah Khalifa, Master cardiology
- Email: mostafaabdallahkhalifa@med.asu.edu.eg
- Phone: +201012988025
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Adenosine given before primary PCI to reduce no-reflow in STEMI patients.
See if giving intracoronary adenosine before primary PCI lowers the chance of slow flow/no-reflow in adults with STEMI.
-
Brain blood flow changes after successful clot removal in acute ischemic stroke
This study will use a special MRI blood-oxygenation breathing test to see if it can detect patients with acute ischemic stroke who do not improve after successful clot removal.
-
Using cardiac MRI and AI to predict outcomes after STEMI
This project will try to use routine cardiac MRI scans plus AI to see if imaging features can predict long-term outcomes in people who had a STEMI treated with primary PCI.
-
Using beta-blockers for heart attack patients in intensive care
This study is testing if the heart medication metoprolol can help heart attack patients in intensive care feel better and avoid worsening their condition.
-
Using an aspiration catheter for treating heart attacks
This study tests whether using a special catheter can help remove blood clots from the heart arteries during a heart attack to improve blood flow and patient recovery.
-
Using machine learning to improve early diagnosis of acute cardiovascular conditions
This study is testing a new tool that uses advanced computer technology to help doctors quickly and accurately diagnose serious heart problems in patients who come to the emergency room with chest pain or trouble breathing.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.