Adding physical exercise to chemotherapy for breast cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of a physical exercise intervention on the efficacy of neoadjuvant chemotherapy in women with newly diagnosed breast cancer. The study involves a randomized controlled design where participants will be assigned to either receive chemotherapy alone or chemotherapy combined with a structured exercise program. The primary goal is to evaluate the rate of pathologic complete response (pCR) between the two groups, while secondary outcomes will assess treatment tolerability, immune response, physical fitness, and quality of life. The trial aims to determine if exercise can enhance the effectiveness of chemotherapy in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. being female gender;
2. age equals or greater than 18 years old;
3. having a newly diagnosed histologically confirmed breast carcinoma IA-IIIC;
4. planned to receive neoadjuvant chemotherapy with anthracyclines or taxanes, that might be associated to anti-HER2 drugs;
5. being followed by the oncology department of the CHVNG/E;
6. medical oncologists consents the practice of physical exercise;
7. the patient is capable of providing written informed consent;
8. the participant accepts to be allocated to the control or experimental group, according to the randomization.

Exclusion Criteria:

1. previous cancer diagnostic;
2. evidence of synchronous oncologic disease;
3. physical or psychiatric contraindication to the practice of physical exercise.

Where it's running

• Centro Hospitalar Vila Nova Gaia e Espinho
  Vila Nova de Gaia, Porto District, Portugal Recruiting

Study contacts

• Principal investigator: Nuno Rato, MSc — University of Maia
• Study coordinator: Nuno D Rato, MSc
• Email: nuno.rato@umaia.pt
• Phone: +351 919985852

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.