Adding dairy to a Canadian Food Guide diet and gut health
Impact of Dairy Integration Into Canadian Food Guide on Gut Health
This will test whether adding milk or fermented milk to a Canadian Food Guide–based diet changes gut bacteria, gut permeability, and inflammation in 45–65-year-olds with abdominal obesity and mild metabolic changes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 40 Years to 65 Years |
| Sex | All |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Trial ID | NCT07257913 on ClinicalTrials.gov |
What this trial studies
This single-blinded crossover trial will enroll about 20 middle-aged men and women with abdominal obesity and slightly deteriorated lipid or glucose profiles. Participants will complete three controlled-feeding phases in random order—each including a short run-in and a period consuming a Canadian Food Guide–based diet with either soy beverage (control), milk, or fermented milk—separated by 14–28 day washouts. The team will collect stool, blood, and permeability measures to profile gut microbiota composition, trans-epithelial permeability, and inflammatory markers. The fully controlled feeding design provides precise nutrient intake to detect short-term effects of dairy versus a plant-based alternative on gut health.
Who should consider this trial
Good fit: Ideal candidates are 45–65-year-old men and women with waist circumference >80 cm (women) or >94 cm (men) and mildly abnormal lipids or glucose who are non-diabetic and able to attend in-person visits in Québec.
Not a fit: People with diagnosed diabetes, major cardiovascular or immune disease, recent antibiotic use, lactose intolerance or relevant food allergies, active smoking or pregnancy/lactation are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could show that milk or fermented milk improves gut microbiota balance and reduces gut permeability or inflammation, helping refine dietary guidance for people with abdominal obesity.
How similar studies have performed: Previous controlled-feeding and fermented-dairy studies have shown that diet and fermented milk can modify gut microbiota and some inflammatory markers, but dairy-specific effects in this exact population remain incompletely tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * IMC \< 45 * Waist circumference \> 80 cm (Women) or 94 cm (men) Exclusion Criteria: * History of diabetes (types 1 and 2), CVD, enteropathy, immune diseases or bariatric surgery * Cancer (diagnostic and/or treatment) during the last 5 years * Antibiotic consumption during the last 3 months * Active smoking or cannabis consumption * Lactose intolerance or allergy, any allergies to foods given in the intervention phases * Irregular defecation patterns * Pregnancy/lactation * Inability to speak French
Where this trial is running
Québec, Quebec
- Institute of Nutrition and Functional Foods (INAF) — Québec, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Alain Veilleux, PhD — Laval University
- Study coordinator: Alain Veilleux, PhD
- Email: alain.veilleux@fsaa.ulaval.ca
- Phone: 418 656-2131
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.