Adaptive radiation therapy for cervical cancer using MRI technology

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores the feasibility of using a magnetic resonance imaging (MRI)-only approach for adaptive external beam radiation therapy (EBRT) in patients with cervical cancer. By implementing the Varian Ethos therapy system, the study aims to streamline the treatment workflow and reduce the radiation dose to surrounding organs at risk by adapting the treatment to the patient's daily anatomy. The focus is on patients requiring curative treatment for specific stages of cervical cancer, utilizing MRI for precise treatment planning.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years old
* Histologically proven cervical cancer (SCC, ADK ou adenous-SCC)
* Patient for curative RTCT treatment
* FIGO/TNM Stage IB2, IIA, IIB, IIIA, IIIB with or without lymph nodes involvement
* WHO \< 2
* No pregnancy
* Informed consent dated and signed
* Patient affiliated or beneficiary of a social security scheme
* Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).

Exclusion Criteria:

* Metastatic disease
* Contraindications to IRM examinations (claustrophobia, presence of metallic elements..)
* Signes of active infection or serious health problems
* Historic of abdominal or pelvis RT
* Surgical history: partial or total hysterectomy

Where it's running

• Institut Sainte Catherine
  Avignon, France Recruiting

Study contacts

• Study coordinator: Catherine Khamphan, PhD
• Email: c.khamphan@isc84.org
• Phone: 0490276543

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.