Active oxygen-releasing gel with light therapy for advanced gum disease

Evaluation of Active Oxygen Releasing Gel Combined With Photodynamic Therapy in The Treatment of Stage III Periodontitis (A Randomized Controlled Clinical Trial)

This test sees if adding an oxygen-releasing gel, with or without a light-based photodynamic therapy, to standard deep cleaning helps people with stage III periodontitis.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 42 (estimated)
• Ages: 30 Years to 70 Years
• Sex: All
• Sponsor: Alexandria University (Academic / other)
• Locations: 1 site (Alexandria, Bab Sharq)
• Trial ID: NCT07368699 on ClinicalTrials.gov

What this trial studies

This randomized clinical trial will enroll 42 adults with stage III periodontitis and assign them to one of three groups: scaling and root planing (SRP) alone, SRP plus a topical active oxygen-releasing gel, or SRP plus the gel together with photodynamic therapy using a diode laser and photosensitizer. The oxygen-releasing gel is applied to the gums and is intended to reduce harmful bacteria by releasing oxygen locally, while photodynamic therapy uses a dye and light to target bacteria. Clinical outcomes such as pocket depth, clinical attachment levels, and gingival inflammation will be compared between groups over the study follow-up. Eligible participants are adults 30–70 years old, non-smokers, without systemic conditions that affect periodontal healing and without recent periodontal treatment or recent antibiotics/anti-inflammatories.

Who should consider this trial

Good fit: Adults aged 30–70 with stage III periodontitis, residual periodontal pockets ≥4 mm and clinical attachment loss ≥5 mm, who are non-smokers and have not had periodontal treatment in the prior 3 months.

Not a fit: Smokers, people with systemic conditions that affect healing (such as diabetes), pregnant or lactating women, those who used antibiotics or anti-inflammatory drugs recently, and people with parafunctional habits are unlikely to benefit or are excluded.

Why it matters

Potential benefit: If successful, adding the gel and photodynamic therapy could reduce pocket depth and gum inflammation beyond deep cleaning alone, helping preserve tooth support and oral health.

How similar studies have performed: Previous studies of photodynamic therapy as an adjunct to scaling and root planing have shown mixed but sometimes modest improvements, while active oxygen-releasing gels are a newer approach with limited published evidence.

Eligibility criteria

Inclusion Criteria:

* Patients with periodontal diagnosis of stage III periodontitis
* Patients with residual periodontal pocket depth ≥4 mm ,CAL≥ 5mm with bone loss extending to middle third of root and beyond in radiography
* Bleeding on probing at least four sites at base-line
* Patients who didn't receive periodontal treatment for a minimum of 3 months prior to the examination.
* Patients of both sexes aged ≥30 and ≤70 years

Exclusion Criteria:

* Smokers or those with any other harmful habits such as pipe or vape smoking
* Patients with any systemic condition that will possibly affect the outcome of periodontal therapy i.e. (diabetic patients)
* Patients who have received any local or systemic anti-inflammatory medications or antibiotics within the last 6 months
* Pregnant or lactating women
* Patients with parafunctional habits

Where this trial is running

Alexandria, Bab Sharq

• Faculty of Dentistry, Alexandria University — Alexandria, Bab Sharq, Egypt (Recruiting)

Study contacts

• Principal investigator: Mohey eldin Elrashidy, PhD,prof — Faculty of Dentistry periodontology department Alexandria University,Egypt.
• Study coordinator: Aya Abdelmawla, BDS

Conditions Stage III Periodontitis; Active oxygen releasing gel; Photodynamic therapy; Periodontitis; Scaling and Root Planing,