Activated charcoal to lower phosphate in adults on hemodialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2 interventional trial enrolling adults with end-stage renal disease who have been on stable thrice-weekly hemodialysis for at least six months. Participants are already receiving phosphate binders per KDIGO guidance and will receive activated charcoal as the experimental intervention alongside or in place of conventional binders to study its effects. The trial focuses on whether oral activated charcoal improves serum phosphate control and has a favorable tolerability and safety profile compared with standard phosphate binders. Key eligibility criteria exclude severely malnourished patients, those treated with overnight dialysis, and patients with primary hyperparathyroidism or very high intact parathyroid hormone levels.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult aged ≥18 years with ESRD.
2. Patients who had been on stable maintenance hemodialysis (3 times weekly) for at least 6 months.
3. Patients receiving phosphate binders according to standard protocols established by kidney disease: Improving Global Outcomes (KDIGO).

Exclusion Criteria:

1. Severely malnourished (as diagnosed by the department's dietitian).
2. Treated with overnight dialysis.
3. Primary hyperparathyroidism or persistent serum levels of intact parathyroid hormone greater than 800 pg/mL.

Where it's running

• Urology and Nephrology Center
  Al Mansurah, Please Select, Egypt Recruiting

Study contacts

• Study coordinator: Basma M. Sayed Ahmed, M.Sc.
• Email: basma_mohamed@mans.edu.eg
• Phone: +201207753307

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.