Accelerated TMS treatment for depression
Official title: Vastra Gotaland Region Accelerated Transcranial Magnetic Stimulation Treatment for Depression
Run by Vastra Gotaland Region · NCT06138678 · Data updated 2026-11-12
This study is testing if a faster treatment using brain stimulation can help people with depression feel better compared to the usual slower method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 146 (estimated) |
| Sponsor | Vastra Gotaland Region Government |
| Locations | 2 sites (Kungälv and 1 other locations) |
| Status | Recruiting |
| Started | January 15, 2024 |
| Main results expected | January 1, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | November 25, 2024 |
| Trial ID | NCT06138678 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults diagnosed with depression who meet specific inclusion criteria and have not undergone recent TMS or ECT.
✕Probably not a fit
Patients with a history of substance abuse, pregnancy, epilepsy, or certain implanted devices may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of an accelerated intermittent theta burst stimulation (iTBS) protocol compared to a routine iTBS protocol for treating depression. Participants will receive either 1200 pulses per session twice a day over 15 days or 600 pulses per session once a day over 30 days. A total of 146 patients diagnosed with depression will be recruited and randomized to one of the treatment protocols. Their depressive symptoms will be assessed by psychiatrists at 3 and 6 weeks post-treatment, along with self-rating questionnaires throughout the study.
Why it matters
Potential benefit: If successful, this treatment could provide a faster and more effective option for patients suffering from depression.
How similar studies have gone: Previous studies have shown promising results with iTBS for depression, suggesting that this accelerated approach may also be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of depression verified through a Mini International Neuropsychiatric Interview (M.I.N.I.) * MADRS-S \>= 20 * unchanged medication last month * unchanged psychological treatment last month * admitted to psychiatric ward last month * no ECT or TMS last six months * provision of signed informed consent form * indication for TMS is depression Exclusion Criteria: * addiction (illicit drugs or alcohol) * pregnancy * epilepsy * conductive ferromagnetic or other metals implanted in the head or within 30 cm of the treatment coil * implanted device that is activated or controlled in any way by physiological signals * implanted mediation pumps * intracardiac lines, even when removed * regular use of benzodiazepines * any condition that seriously increases the risk of non-compliance or loss of follow-up
Where it's running
-
Kungälv Hospital
Kungälv, Sweden Recruiting -
Hospital of Skövde
Skövde, Sweden Recruiting
Study contacts
- Principal investigator: Melker Hagsäter, MD, MSc, PhD — Västra Götaland Regional Council
- Study coordinator: Melker Hagsäter, MD, MSc, PhD
- Email: melker.hagsater@vgregion.se
- Phone: +46 3039 8000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.