ABSK141 for advanced solid tumors with KRAS G12D mutation

A Phase I/II, Open-Label Study of ABSK141 to Assess Safety, Tolerability, Efficacy and Pharmacokinetics in Patients With KRAS G12D Mutant Advanced Solid Tumors

This trial tests an oral drug called ABSK141 to see if it is safe and helps adults with advanced solid tumors that have a KRAS G12D mutation.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 401 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Abbisko Therapeutics Co, Ltd (Industry-sponsored)
• Drugs / interventions: chemotherapy, immunotherapy
• Locations: 1 site (Shanghai)
• Trial ID: NCT07417189 on ClinicalTrials.gov

What this trial studies

This first-in-human, open-label Phase 1/2 program administers oral ABSK141 in a dose-escalation phase to define safety, tolerability, and pharmacokinetics and to establish recommended doses for expansion. Backfill cohorts and an expansion phase enroll patients whose tumors harbor the KRAS G12D mutation, focusing on colorectal cancer, non-small cell lung cancer, and pancreatic ductal adenocarcinoma, with at least one measurable lesion per RECIST 1.1. The Phase 2 portion gives the recommended phase 2 dose to further test safety and efficacy in selected tumor types. Standard oncology endpoints and PK sampling will guide dose selection and early signs of anti-tumor activity.

Who should consider this trial

Good fit: Adults (18+) with histologically confirmed locally advanced or metastatic solid tumors harboring a KRAS G12D mutation—especially CRC, NSCLC, or PDAC—with at least one measurable lesion and adequate organ function are eligible.

Not a fit: Patients without a KRAS G12D mutation, those with early-stage disease, poor performance status, or who cannot take oral medications are unlikely to benefit from this study.

Why it matters

Potential benefit: If successful, ABSK141 could provide a targeted oral option that slows tumor growth for patients with KRAS G12D–mutant cancers.

How similar studies have performed: KRAS G12C inhibitors have demonstrated clinical benefit, but direct targeting of KRAS G12D is newer and has limited clinical data so far.

Eligibility criteria

Inclusion Criteria:

1. Patients should understand, sign, and date the written informed consent form prior to screening
2. Male or female age 18 years or older
3. Patients with histologically confirmed locally-advanced or metastatic solid tumors .

For backfill cohorts in the escalation part:

1. Patients must have the following solid tumor harboring KRAS G12D mutation:

   1. Colorectal cancer (CRC);
   2. Non-small cell lung cancer (NSCLC);
   3. Pancreatic ductal adenocarcinoma (PDAC);
2. Patients must have at least one measurable target lesion according to RECIST 1.1

For expansion Part:

1. Patients must have the following solid tumor harboring KRAS G12D mutation:

   1. Colorectal cancer (CRC);
   2. Non-small cell lung cancer (NSCLC);
   3. Pancreatic ductal adenocarcinoma (PDAC);
   4. Other solid tumors;
2. Patients must have at least one measurable target lesion according to RECIST 1.1

For phase II:

1. Patients with locally advanced or metastatic solid tumors confirmed by histological examination, whose disease has progressed after standard treatment or who are intolerant to standard treatment, or for whom there is currently no standard treatment.
2. Patients must have the following solid tumor harboring KRAS G12D mutation:

   1. Colorectal cancer (CRC);
   2. Non-small cell lung cancer (NSCLC);
   3. Pancreatic ductal adenocarcinoma (PDAC);
   4. Other solid tumors;
3. Patients must have at least one measurable target lesion according to RECIST 1.1 4. ECOG performance status 0 or 1 5. Adequate organ function and bone marrow function as indicated by the following screening assessments performed within 14 days prior to the first dose of study drug 6. For patients participating exploration of food effect:

(1) be able to eat a standardized high-fat, high caloric meal within 30 minutes (2) be able to fast for 10 hours

Exclusion Criteria:

1. Known allergy or hypersensitivity to any component of the investigational product
2. (For backfill cohorts and expansion part) Patients who were previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy
3. Has a known additional malignancy that is progressing or has required active treatment
4. Unable to swallow capsules or tablets or malabsorption syndrome, disease significantly affecting GI function, or resection of the stomach or small bowel, symptomatic inflammatory bowel disease or ulcerative colitis, or partial or complete bowel obstruction. If any of these conditions exist, the site should discuss with the sponsor to determine patient eligibility
5. Previous anti-tumor therapy, including chemotherapy, endocrine therapy, molecular targeted therapy or other investigational drugs received ≤2 weeks or ≤5-half life (whichever is shorter), radiotherapy and antibody therapy received ≤4 weeks prior to initiation of study treatment
6. Major surgery within 4 weeks of the first dose of study drug. Note that all surgical wounds must be healed and free of infection or dehiscence
7. Prior toxicities from chemotherapy, radiotherapy, and other anti-cancer therapies, including immunotherapy, that have not regressed to Grade ≤1 severity (CTCAE v5.0)
8. Patients should not use proton pump inhibitors for at least 7 days prior to the first dose of ABSK141 and during treatment with ABSK141.
9. P-gp inhibitor and strong CYP3A inhibitors to 7 days or 5 half-lives whichever is longer and for CYP3A inducers to 2 weeks or 5 half-lives
10. Active central nervous system (CNS) metastases
11. History of interstitial lung disease requiring systemic steroid treatment.
12. Impaired cardiac function or clinically significant cardiac disease
13. NSCLC cohorts: Patient previously identified as having a driver mutation (according to local standard of care or guidelines) and have not received any targeted therapy, for example: EGFR mutation, ALK rearrangement, KRAS G12C mutation, NTRK1/2/3 gene fusion, RET fusion, MET exon14 skipping mutation, BRAF V600E mutation, ROS1 rearrangement, etc
14. Known acquired immunodeficiency syndrome (AIDS)-related illness, or positive test for HIV 1/2 antibody
15. Exclusion of hepatitis infection
16. Patients with refractory/uncontrolled ascites or pleural effusion
17. Pregnant or nursing (lactating) women
18. refuse to use highly effective methods of birth control during the study and for up to 6 months after the last dose of study drug.
19. Sexually active males who refuse to use a condom during intercourse while taking drug and for 5 consecutive compound half-lives plus 60 days after stopping study drug.
20. Vaccination with a live, attenuated vaccine within 4 weeks prior to the first dose of study treatment except for administration of inactivate vaccines
21. Planned major surgery during study treatment
22. Any other clinically significant comorbidities

Where this trial is running

Shanghai

• Fudan University Shanghai Cancer Center — Shanghai, China (Recruiting)

Study contacts

• Principal investigator: Xianjun Yu, Doctor — Fudan University
• Study coordinator: Yu Zhang, Bachelor

Conditions Solid Tumors, Adult; ABSK141; KRAS G12D