A program to help people with chronic conditions quit smoking

The Positively Quit Trial: Addressing Disproportionate Smoking Rates Among People Living With HIV

NA · University of South Florida · NCT04449458

This study is testing a special online program to help people with chronic conditions quit smoking and see if it works better than a regular support program.

Quick facts

PhaseNA
Study typeInterventional
Enrollment482 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of South Florida (other)
Locations1 site (Tampa, Florida)
Trial IDNCT04449458 on ClinicalTrials.gov

What this trial studies

This trial aims to evaluate the effectiveness of a smoking cessation program specifically designed for individuals living with certain chronic conditions, delivered through videoconferencing. Participants will be divided into two groups: one receiving the tailored cessation program and the other receiving an Attention Matched Control program that does not focus on smoking cessation. Both groups will receive brief advice to quit and nicotine replacement therapy patches, along with 12 group sessions conducted online. The study will measure smoking behavior over a year to determine which program is more effective in helping participants quit smoking.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who smoke cigarettes, are motivated to quit, and are living with certain health conditions.

Not a fit: Patients who are pregnant, breastfeeding, or have contraindications to nicotine replacement therapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve smoking cessation rates among individuals with chronic conditions.

How similar studies have performed: Other studies have shown success with similar smoking cessation approaches, particularly those tailored for specific populations.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* greater than or equal to age 18 (as NRT is not FDA approved for adolescents)
* self-report smoking cigarettes
* positive cotinine test
* motivated to quit
* own a smart phone, laptop, desktop, or tablet computer
* able to join group from a private space with Internet access
* demonstrate the ability to connect to the HIPAA-compliant videoconferencing system, Zoom, over the internet h) speak English i) living in the US j) living with certain health conditions

Exclusion Criteria:

* pregnant, breastfeeding, or have other contraindications to NRT
* receiving other tobacco treatment, or
* inability to communicate coherently in English during the video-conferencing test or other pre-enrollment interactions

Where this trial is running

Tampa, Florida

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Cigarette Smoking

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.