A new medication for treating Borderline Personality Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the efficacy of an NMDA receptor antagonist in treating Borderline Personality Disorder (BPD), a condition characterized by emotional dysregulation and impulsive behaviors. Participants aged 18-65 with a confirmed diagnosis of BPD will be enrolled and randomly assigned to receive either the active drug or a placebo. The study aims to assess the drug's impact on symptoms and overall functioning in individuals suffering from this debilitating mental illness.

Why it matters

Who can join: the full rules

Inclusion criteria

Participants will be eligible to proceed in the study if they meet all of the following criteria (as determined in the screening session):

1. Men and women aged between 18-65 years of age
2. A current diagnosis of BPD, or a score ≥ 8 on Diagnostic Interview for Borderline patients, or a score ≥ 15 on Zanarini Rating Scale for Borderline Personality Disorder
3. Proficient in reading and writing English

Exclusion criteria

Potential participants who meet the criteria for any of the following will be excluded from participating in the study:

1. Clinical evidence of acute delirium or severe head injury
2. Epilepsy or other current seizure disorder, history of seizures or convulsions (not including febrile convulsions), or presence of predisposing factors for epilepsy.
3. Clinically significant hepatic or renal impairment, haematological, or cardiovascular disease.
4. Concomitant use of NMDA antagonists (amantadine, ketamine, dextromethorphan), L-dopa, dopamine agonists or anticholinergics.
5. Lifetime diagnosis of schizophrenia, schizoaffective disorder, substance-induced psychotic disorder or bipolar I disorder (DSM-V).
6. Risk of suicide such that inpatient admission is required, as determined by PI (psychiatrist) on the basis of clinical assessment and baseline BPDSI-IV and/or ZAN-BPD suicide subscale scores.
7. Taking more than 4 psychotropic medications.
8. Planned changes to psychotropic medication or psychotherapy regime.
9. Substance abuse or dependence requiring intervention or rehabilitation in last 3 months.
10. Pregnant or breastfeeding; if of child-bearing age, not using appropriate contraceptive precaution.

Where it's running

• Monash Alfred Psychiatry Research Centre
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Principal investigator: Jayashri Kulkarni AM, MBBS,MPM,FRANZCP,PhD — Bayside Health, Alfred Hospital
• Study coordinator: Jayashri Kulkarni AM, MBBS,MPM,FRANZCP,PhD
• Email: j.kulkarni@alfred.org.au
• Phone: +61 3 90766924

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• See if Borderline Personality Disorder can be viewed as a Relationship-Use Disorder

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• rTMS (noninvasive brain stimulation) for borderline personality disorder

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• Evaluating a new treatment approach for borderline personality disorder

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• Physical activity for people with schizophrenia, borderline personality disorder, or vestibular disorders

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  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT06817980

• Training to improve emotion regulation in people with Borderline Personality Disorder

  This study is testing a new training program to help people with Borderline Personality Disorder learn better ways to manage their emotions.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06772831

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.