A method to predict radiation-induced mouth sores in cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate a new mucosal contouring method based on swallowing-induced breakthrough pain to predict the occurrence of radiation-induced oropharyngeal mucositis in patients with nasopharyngeal carcinoma. The study will involve multiple centers and focus on patients undergoing radical radiotherapy or chemoradiotherapy. By identifying high-risk patients through this innovative predictive model, the study seeks to improve patient outcomes and quality of life. The researchers will analyze the effectiveness of this method compared to traditional contouring approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Provide informed written consent.
2. Age ≥ 18 years.
3. Histologically confirmed as nasopharyngeal carcinoma, and currently undergoing radical radiotherapy or chemoradiotherapy.
4. Complete and continuous records of oral / oropharyngeal mucositis grading, and self-reported swallowing-induced breakthrough pain.

Exclusion Criteria:

1. Existence of poor oral hygiene, untreated dental or periodontal diseases, and metal dental restorations.
2. Current untreated or unresolved conditions like unstable heart diseases requiring treatment, and poorly controlled diabetes mellitus.
3. Body mass index (BMI) \<18.5.
4. Unsuitable to participate in current study, according to researchers' assessment.

Where it's running

• Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Jian Guan, Ph.D. — Nanfang Hospital, Southern Medical University
• Study coordinator: Jian Guan, Ph.D.
• Email: guanjian5461@163.com
• Phone: +86-13632102247

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• TCM oral liquid plus herbal mouthwash for radiation‑caused mouth sores in head and neck cancer

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• Taurine to prevent radiation-induced mouth sores and skin reactions

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  Recruiting Phase 2 Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality · NCT07029178

• Using hydroxychloroquine to prevent and treat oral mucositis from radiation therapy

  This study is testing if hydroxychloroquine can help prevent and treat mouth sores in people getting radiation therapy for head and neck cancer.

  Recruiting Phase 1/2 West China Hospital · Chengdu, Sichuan · NCT06939582

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.