8-day OliPhenolia® supplementation to increase fat burning during exercise
The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation in Recreationally Active Volunteers
This study will test whether 8 days of the olive-extract drink OliPhenolia® — with or without a caffeinated pre-workout drink — helps healthy, recreationally active adults burn more fat during cycling exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Anglia Ruskin University Academic / other |
| Locations | 1 site (Cambridge) |
| Trial ID | NCT07210099 on ClinicalTrials.gov |
What this trial studies
About 30–40 healthy, recreationally active adults will be recruited and screened before baseline fitness testing. Participants will complete a graded cycling test to determine VO2peak and a Fatmax protocol with a 30-minute steady-state bout while breath-by-breath gas exchange measures fat oxidation. After baseline testing participants will be randomized into one of four groups to take OliPhenolia® or placebo for 8 days and will receive either a caffeinated pre-exercise beverage or placebo at the follow-up test. The main outcome is change in maximal fat oxidation (Fatmax) measured by respiratory gases comparing pre- and post-supplementation and the interaction with acute caffeine.
Who should consider this trial
Good fit: Healthy UK adults over 21 years old with BMI 18–30 kg/m2 who are recreationally active (about 150 minutes/week) and have VO2peak between 20 and 50 mL·kg−1·min−1.
Not a fit: People outside the BMI or fitness ranges, those with cardiovascular disease, diabetes, or on medications that affect exercise, or those unable to perform cycling exercise are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If effective, the drink could help recreational exercisers increase fat oxidation during moderate aerobic workouts, which may support weight or metabolic health management.
How similar studies have performed: Previous work by the same investigators showed antioxidant effects and reduced oxygen cost with this olive extract, but no prior trials have tested short-term effects on fat oxidation and broader polyphenol plus caffeine research has reported mixed results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women, UK based, above 21 years of age with a body mass index (BMI) \>18 and \<30 kg·m2 determined during baseline testing * Considered to be recreationally active i.e. approximately 150mins of general physical activity/ exercise per week (meeting the WHO physical activity guidelines); and a VO2peak (fitness) score \>20 and \<50 mL·kg-1·min-1 determined during baseline testing. * No known history (including family history) of heart abnormalities, hypertension, coronary heart disease or diabetes (determined from pre-study health screen questionnaire). * Not currently suffering from any musculoskeletal injury, or any other reason that may prevent participation in cardiovascular exercise. * Have not suffered from recent viral infections ie: influenza (defined within the prior 2 months). * Not taking any prescribed or over-the-counter medication which may influence exercise training (with the exception of inhalers for exercise induced asthma or contraceptive pill). * Not consuming or prepared to refrain from consumption, any commercial supplementation which conflicts with the study parameters ie: antioxidants. * No known allergy or intolerance to olives or prune/grape juice, or any known side effects from caffeine ingestion. Exclusion Criteria: * If any of the above criteria is not met.
Where this trial is running
Cambridge
- Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, — Cambridge, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Justin D Roberts, Professor — Anglia Ruskin University
- Study coordinator: Justin D Roberts, Professor
- Email: justin.roberts@aru.ac.uk
- Phone: 07794122020
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.