24-hour IV lidocaine to reduce lung complications after emergency abdominal surgery for infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing emergency laparotomy for intra-abdominal infection receive either a continuous 24-hour intravenous infusion of lidocaine or a placebo during general anesthesia. The primary outcome is incidence of postoperative pulmonary complications within two days, including unplanned ventilation, acute respiratory distress syndrome, or postoperative pneumonia. Secondary outcomes include the proportion requiring mechanical ventilation, perioperative organ function, length of hospital stay, and 30-day postoperative outcomes. Standard infection markers and surgical exclusion criteria are used to screen participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years, any gender.
* Patients suspected of digestive tract perforation or obstruction based on physical examination, confirmed by imaging, requiring emergency surgical treatment.
* The anesthesia method is general anesthesia
* I or the patient's family have carefully read and signed the informed consent form
* Serum procalcitonin (PCT) at inflammatory levels or leukocytosis (\>12×109/L) or leukopenia (\<4×109/L) or \>10% naive leukocytes

Exclusion Criteria:

* Have a history of local anesthesia drug allergy
* Pregnant patients
* Patients receiving renal replacement therapy
* Patients with arrhythmias or heart failure (second or third-degree atrioventricular block or left ventricular ejection fraction（LVEF）
* Preoperative platelet count\<80 × 109/L
* Patients who require secondary surgery for postoperative anastomotic fistula
* Patients who have participated in other clinical studies

Where it's running

• Zhongshan Hospital,Fudan university
  Shanghai, Shanghai Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.