Study summary
Testosterone therapy did not raise heart attack or stroke risk in pooled trials
5,601men in 35 placebo-controlled trials
What was tested
A large pooled review, including individual patient data, of placebo-controlled trials of testosterone therapy in men with low testosterone.
What they found
- Heart and stroke events were similar with testosterone and placebo.
- Event definitions varied across trials.
What it means
Supports testosterone therapy as reasonably safe for the heart in men with true deficiency, monitored by a doctor.
Last reviewed 2026-11-14 by the Find a Trial editorial team.
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