Where low testosterone treatment is heading
Low testosterone · Updated Nov 13, 2026
Low testosterone (male hypogonadism) can cause low sex drive, erectile problems, fatigue, low mood and bone loss. Treatment is testosterone by gel, injection, pellet or pill. Research now focuses on safety, easier delivery, and keeping fertility.
- 36studies open or running
- 4phase 3 trials
- 170papers published this year
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Now
Nov 2026
Heart safety looks reassuringHappened 5,601 men pooled
Across 35 trials and 5,601 men, heart and stroke events matched placebo.
5,601: men in 35 placebo-controlled trials.
Testosterone pills workHappened 87.4% reached normal levels
87.4% reached normal levels on oral testosterone undecanoate.
87.4%: reached normal testosterone levels on the pill.
-
6 months
by May 2027
Testosterone for cancer survivorsPossible
Seattle trials test testosterone for fatigue and sexual function in older male cancer survivors; due 2026–2027.
-
12 months
by Nov 2027
Easier weekly injectionsPossible
A 190-person phase 3 of a weekly cypionate auto-injector finishes March 2027.
-
3 years
by late 2029
Testosterone around prostate cancer surgeryLong shot
ENFORCE tests whether testosterone gel around surgery affects cancer and function outcomes; due December 2027.
Pain and opioid-related low testosteroneLong shot
A Brigham trial tests whether testosterone eases pain in men on long-term opioids.
-
5 years
by late 2031
Restarting the body's own testosteroneLong shot
Trials test tamoxifen and clomiphene to restore natural production, protecting fertility.
The research paths
Delivery methods
87.4% reached normal levelsDetails and 2 trialsHide
Pills, auto-injectors and implants for easier treatment.
WatchAuto-injector trials.
New groups of patients
5,601 men pooledDetails and 3 trialsHide
Cancer survivors, men on opioids, and men after prostate cancer.
WatchSeattle and Brigham results.
- Testosterone around prostate surgery (ENFORCE)Canisius-Wilhelmina Hospital · 140 people · enrolling Dec 2027
- Testosterone for cancer survivorsSeattle Institute for Biomedical and Clinical Research · 240 people · enrolling Jan 2027
- Testosterone for opioid-related low testosteroneBrigham and Women's Hospital · 150 people · enrolling Sep 2027
Fertility-sparing options
Details and 1 trialsHide
Drugs that restart natural testosterone production.
WatchTamoxifen trial.
Borrowed from other conditions
From Breast cancer
Tamoxifen
Phase 2
Blocks estrogen feedback so the body makes more testosterone.
From Female infertility
Clomiphene
Off-label use
Raises the hormones that drive testosterone and sperm production.
Open to join now
-
Men with hypogonadism
Weekly cypionate auto-injector
Locations and eligibility → -
Cancer survivors with fatigue
Testosterone undecanoate injection
Locations and eligibility → -
Men on long-term opioids
Testosterone undecanoate
Locations and eligibility → -
Testosterone recovery
Tamoxifen
Locations and eligibility →
See every recruiting Low testosterone trial →
When the trials finish
Completion dates the trials registered. Results usually follow 3 to 12 months later.
- Heating up
- Maturing
- Early
- Cooling
- Fully enrolled, waiting on results
- Still enrolling
What just happened
No added heart risk in pooled trials
35 trials, 5,601 men.
Standard treatment today
- DiagnosisTwo morning blood tests showing low testosterone plus symptoms.
- TreatmentTestosterone gel, injection, pellets or oral capsules, with blood count and PSA monitoring.
- Wanting childrenAvoid testosterone; use clomiphene, hCG or similar to keep sperm production.
- Overweight or diabeticWeight loss often raises testosterone; treat if symptoms persist.
How to read this page, and sourcesHow to read this page, and sources
- Testosterone is not for men with normal levels or those trying to have children.
- Forecasts are editorial judgments by Find a Trial, not predictions from sponsors or regulators.
See Low testosterone trials recruiting now →