Study summary

Gene study points to skin-cell keratin pathways as the backbone of HS

HS genetics study · 4,814 cases · Published December 2024, Journal of the American Academy of Dermatology

8gene variants linked to HS

What was tested

A genome-wide study of 4,814 people with hidradenitis suppurativa and 1.2 million controls in five countries.

What they found

8 gene variants were linked to HS.
Candidate genes (NCSTN, PSENEN, WNT10A, TMED10) sit in Notch and Wnt pathways that control skin keratin.
Mostly European populations were studied.

What it means

Suggests treatments aimed at hair follicle and skin-cell behavior, not only inflammation.

J Am Acad Dermatol, via PubMed ↗ ← Back to the outlook

Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.