Sponsor or institution

Clinical trials and research at Cogent Biosciences, Inc.

• 4Clinical trials
• 25Countries

Newest trials

All recruiting trials (4)

• Mutant-selective inhibitor CGT6297 in advanced solid tumors with PIK3CA mutations

  This phase 1 study tests CGT6297 to see if it is safe and tolerable, and to get an early sense of activity, in adults with advanced solid tumors that have PIK3CA mutations.

  Recruiting at 12 sites Phase 1 Cogent Biosciences, Inc. · Scottsdale, Arizona and 11 other locations · NCT07383506

• Selective ERBB2 inhibitor CGT4255 for adults with ERBB2-altered advanced solid tumors

  This trial tests a targeted drug called CGT4255 in adults with advanced solid tumors that have ERBB2 (HER2) changes to see if it is safe and shows anti-tumor activity.

  Recruiting at 15 sites Phase 1 Cogent Biosciences, Inc. · Scottsdale, Arizona and 14 other locations · NCT07361562

• (Peak) CGT9486 plus Sunitinib vs Sunitinib in advanced or metastatic GIST

  This study tests whether adding CGT9486 to sunitinib helps people with advanced or metastatic GIST who have already tried other treatments.

  Recruiting at 8 sites Phase 3 Cogent Biosciences, Inc. · Birmingham, Alabama and 125 other locations · NCT05208047

• Bezuclastinib treatment for advanced systemic mastocytosis

  This study is testing a new treatment called bezuclastinib to see if it can help people with advanced systemic mastocytosis feel better and manage their symptoms.

  Recruiting at 18 sites Phase 2 Cogent Biosciences, Inc. · Birmingham, Alabama and 41 other locations · NCT04996875

Quick answers

How many clinical trials run by Cogent Biosciences, Inc. are recruiting right now?

4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (4 trials), Australia (2 trials), Canada (2 trials), France (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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