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Clinical trials and research at Children's Oncology Group

• 31Clinical trials
• 9Countries

Newest trials

All recruiting trials (31)

• Guiding melanoma surgery in children using pathology and genetics

  This pediatric phase 2 trial tests whether using tumor pathology and genetic information to classify risk can guide safer, more appropriate surgery for localized skin melanocytic tumors.

  Recruiting at 13 sites Phase 2 Children's Oncology Group · Oakland, California and 12 other locations · NCT07621614

• Higher-dose chemo over a shorter time vs lower-dose chemo with maintenance in newly diagnosed intermediate-risk rhabdomyosarcoma

  We’re testing whether a shorter, higher-dose chemo plan works better than a longer, maintenance chemo plan for kids and young people with intermediate-risk rhabdomyosarcoma.

  Recruiting at 85 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 86 other locations · NCT07466316

• Quality of End-of-Life Care for Children With Cancer

  This study looks at how access to care, family interactions with the healthcare system, and stress relate to the quality of end-of-life care for children with cancer.

  Recruiting at 28 sites Children's Oncology Group · Birmingham, Alabama and 27 other locations · NCT07412002

• Xylitol dental wipes to lower bloodstream infections in kids with AML

  This study tests whether using xylitol dental wipes in children with AML during chemotherapy can reduce bloodstream infections compared with standard dental wipes.

  Recruiting at 38 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 38 other locations · NCT07022678

• Comparing surgery and chemotherapy for treating pleuropulmonary blastoma in children

  This study tests whether combining surgery with chemotherapy is better than just surgery alone for children with pleuropulmonary blastoma, and also looks at adding a new cancer drug to see if it helps kids with more advanced types of the disease.

  Recruiting at 84 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 86 other locations · NCT06647953

• Using triptorelin to protect ovaries in young cancer patients during chemotherapy

  This study is testing if triptorelin can help protect the ovaries of young cancer patients under 40 during chemotherapy to see if it helps maintain their fertility and overall health later on.

  Recruiting at 196 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 205 other locations · NCT06513962

• Culturally-tailored mobile and social media program to increase physical activity in Hispanic/Latino adolescent and young adult childhood cancer survivors.

  This project will test whether a culturally tailored home-based physical activity program delivered via mobile tools and social media can help Hispanic/Latino adolescent and young adult childhood cancer survivors become more active.

  Recruiting at 77 sites Phase 2 Children's Oncology Group · Mesa, Arizona and 76 other locations · NCT06410209

• Using risk factors to guide treatment for children with Wilms tumors

  This study is testing if using specific risk factors can help doctors choose the best treatment for children with Wilms tumors to improve their chances of staying cancer-free.

  Recruiting at 167 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 168 other locations · NCT06401330

• Lower dose radiotherapy for treating children with CNS germinoma

  This study is testing if giving a lower dose of radiotherapy after chemotherapy can effectively treat children with CNS germinomas while reducing side effects.

  Recruiting at 113 sites Phase 2 Children's Oncology Group · Mobile, Alabama and 114 other locations · NCT06368817

• Finding the best dose of imetelstat with chemotherapy for children with certain blood cancers

  This study is testing the best dose of a new drug called imetelstat combined with chemotherapy to see if it can help children with tough blood cancers like leukemia and myelodysplastic syndrome.

  Recruiting at 18 sites Phase 1 Children's Oncology Group · Birmingham, Alabama and 18 other locations · NCT06247787

• Exploring genetic differences in twins with childhood brain tumors

  This study looks at the genetic differences in identical twins who have childhood brain tumors to see how these differences might affect their cancer.

  Recruiting Children's Oncology Group · Minneapolis, Minnesota · NCT06054295

• Letermovir to prevent cytomegalovirus after pediatric stem cell transplant

  This study will try giving letermovir to CMV-positive children and adolescents receiving allogeneic stem cell transplants to see if it lowers CMV infections after transplant compared with the expected rate without prophylaxis.

  Recruiting at 32 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 32 other locations · NCT05711667

• Examining blood cell growth patterns and heart health in Hodgkin lymphoma survivors

  This study is trying to see if certain blood cell changes in people who survived Hodgkin lymphoma can help us understand their heart health better and identify those at risk for heart problems.

  Recruiting at 35 sites Children's Oncology Group · Mobile, Alabama and 35 other locations · NCT05705531

• Understanding the health of individuals with Down syndrome after leukemia treatment

  This study looks at the long-term health and quality of life of people with Down syndrome who have survived leukemia to see how it affects them compared to those who haven't had cancer.

  Recruiting at 73 sites Children's Oncology Group · Birmingham, Alabama and 72 other locations · NCT05702645

• Understanding the long-term effects of pediatric germ cell tumors

  This study is trying to understand the long-term effects of treatment on kids and teens who survived germ cell tumors to see how their health might change over time.

  Recruiting Children's Oncology Group · Minneapolis, Minnesota · NCT05564026

• Treatment for Retinoblastoma Using Eye Injections

  This study is testing if giving children with a specific type of eye cancer an injection of a drug directly into their eye, along with regular chemotherapy, can help treat their condition safely and effectively.

  Recruiting at 17 sites Phase 2 Children's Oncology Group · Birmingham, Alabama and 19 other locations · NCT05504291

• Treatment for childhood medulloblastoma to reduce hearing loss

  This study is testing if giving sodium thiosulfate during chemotherapy can help children with medulloblastoma avoid hearing loss from their treatment.

  Recruiting at 107 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 110 other locations · NCT05382338

• Chemotherapy for very low-risk and low-risk rhabdomyosarcoma

  This study is testing a new chemotherapy plan for patients with very low-risk and low-risk rhabdomyosarcoma to see if it can keep treatment effective while making it easier on them.

  Recruiting at 178 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 180 other locations · NCT05304585

• Comparing two surgical methods for lung cancer in osteosarcoma patients

  This study is testing whether open chest surgery or a less invasive approach is better for helping osteosarcoma patients with lung cancer live longer and feel less pain after surgery.

  Recruiting at 210 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 232 other locations · NCT05235165

• Investigating genetic changes in cord blood from childhood leukemia patients

  This study is trying to understand the genetic changes in cord blood from children with leukemia to see if it can help find early signs of the disease before it develops.

  Recruiting Children's Oncology Group · Minneapolis, Minnesota · NCT05014165

• CBL0137 treatment for relapsed or refractory solid tumors and CNS tumors

  This study is testing a new treatment called CBL0137 to see if it can help children and young adults with tough-to-treat solid tumors and brain tumors feel better.

  Recruiting at 33 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 34 other locations · NCT04870944

• Tegavivint treatment for recurrent or refractory solid tumors in children

  This study tests if a new intravenous medication called tegavivint can help children with tough-to-treat solid tumors, like Ewing sarcoma and desmoid tumors, by finding the right dose and seeing how well it works.

  Recruiting at 19 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 20 other locations · NCT04851119

• New treatment approach for children and young adults with a specific type of brain tumor

  This study is testing a new combination of chemotherapy and radiation therapy to see if it helps children and young adults with a specific type of brain tumor live longer and feel better.

  Recruiting at 160 sites Phase 2 Children's Oncology Group · Birmingham, Alabama and 169 other locations · NCT04684368

• Combination chemotherapy for newly diagnosed and relapsed Wilms tumors

  This study is testing two different chemotherapy treatments to see which one works better for kids with newly diagnosed or relapsed Wilms tumors.

  Recruiting at 192 sites Phase 2 Children's Oncology Group · Birmingham, Alabama and 204 other locations · NCT04322318

• Comparing chemotherapy options for newly diagnosed acute myeloid leukemia

  This study is testing whether a new combination of treatments is better than standard chemotherapy for children and young adults with newly diagnosed acute myeloid leukemia.

  Recruiting at 188 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 205 other locations · NCT04293562

• Using inotuzumab ozogamicin with chemotherapy for high-risk B-cell leukemia

  This study is testing if adding a targeted therapy called inotuzumab ozogamicin to standard chemotherapy can help young patients with high-risk B-cell leukemia live longer without their cancer coming back.

  Recruiting at 212 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 230 other locations · NCT03959085

• Adding iobenguane I-131 or lorlatinib to intensive treatment for children and young adults with high-risk neuroblastoma

  This trial tests whether adding the radioactive drug iobenguane I-131 or the targeted drug lorlatinib to standard intensive therapy helps children and young adults with newly diagnosed high-risk neuroblastoma or nodular ganglioneuroblastoma stay free of disease longer.

  Recruiting at 153 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 163 other locations · NCT03126916

• Monitoring and treating germ cell tumors in children and adults

  This study is testing whether a combination of careful monitoring and chemotherapy can help children and adults with low-risk germ cell tumors stay healthy after surgery, while also comparing two different chemotherapy drugs and looking at their effects on hearing.

  Recruiting at 438 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 628 other locations · NCT03067181

• Gathering health information for younger cancer patients

  This study is gathering health information from younger cancer patients to help improve treatments and support future research.

  Recruiting at 253 sites Children's Oncology Group · Birmingham, Alabama and 278 other locations · NCT02402244

• Effects of dexrazoxane on heart health in cancer survivors

  This study tests if the drug dexrazoxane can help protect the heart health of cancer survivors who had leukemia, lymphoma, or osteosarcoma.

  Recruiting at 62 sites Children's Oncology Group · Birmingham, Alabama and 78 other locations · NCT01790152

• Long-term follow-up for childhood cancer survivors

  This study is trying to keep in touch with childhood cancer survivors to see how they are doing over time and understand the long-term effects of their treatments.

  Recruiting at 139 sites Children's Oncology Group · Birmingham, Alabama and 163 other locations · NCT00736749

Quick answers

How many clinical trials run by Children's Oncology Group are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (31 trials), Canada (19 trials), Australia (13 trials), Puerto Rico (10 trials), New Zealand (8 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 13, Phase 2: 6, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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