Why some people get ARDS and respond differently to treatment
Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress Syndrome
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11146722
This project looks at blood and genetic markers in adults with sepsis-related ARDS to find patterns that could guide different treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11146722 on ClinicalTrials.gov |
What this research studies
The research uses a large, carefully recorded group of over 3,500 critically ill patients with sepsis and collected blood and other samples at multiple timepoints. Doctors and scientists will run genomic and molecular tests on those samples and link the results to who developed ARDS, who recovered, and who did not. The goal is to define immune and molecular subtypes of ARDS that may respond differently to specific therapies. Findings will be used to guide future personalized treatments and new drug targets.
Who could benefit from this research
Good fit: Adults hospitalized with sepsis who develop or are at high risk for ARDS, typically those treated in intensive care units, are the patients most relevant to this work.
Not a fit: People without sepsis-associated ARDS, children, or those with only mild respiratory illness are unlikely to be eligible or directly benefit in the near term.
Why it matters
Potential benefit: If successful, this work could help doctors match treatments to patient subtypes and ultimately reduce deaths from ARDS.
How similar studies have performed: Previous genomic and translational studies have identified candidate markers and subtypes but have not yet produced widely effective drugs, so this builds on promising early work but remains exploratory.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEYER, NUALA JENNINGS — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: MEYER, NUALA JENNINGS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome