Why some people don't regain strength after ARDS
Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors
This project looks at whether lasting immune, hormone, and muscle energy problems explain why some adults who survived ARDS stay weak after leaving the hospital.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11184324 on NIH RePORTER |
What this research studies
If you join, researchers will enroll adults who survived ARDS at hospital discharge and follow them for 12 months. At three months they will bring a subgroup in for in-person testing to compare people who have recovered physically with those who have not. Tests will include blood tests for immune and hormone markers plus measures of muscle function and muscle energy (mitochondrial) performance. The work is being done at Columbia University and Johns Hopkins and aims to find biological reasons for ongoing weakness.
Who could benefit from this research
Good fit: Adults (aged 21 and older) who recently survived ARDS and are willing to attend follow-up visits at the study sites are the ideal candidates.
Not a fit: People who have already fully recovered their physical function, are under 21, or cannot travel for in-person visits are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could identify treatable biological targets to help improve muscle strength and physical recovery after ARDS.
How similar studies have performed: Prior studies have linked inflammation and hormonal changes to muscle weakness after critical illness, but targeted treatments for ARDS-related long-term weakness remain largely unproven.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Baldwin, Matthew R — Columbia University Health Sciences
- Study coordinator: Baldwin, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.