Why gastric cancer rates differ across racial and ethnic groups in the US
Delineating the underlying reasons for the racial disparity in gastric cancer incidence in the United States
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11400611
Researchers will look at whether differences in Helicobacter pylori infection, stomach changes, and related factors help explain higher gastric cancer rates in some racial and ethnic groups in the United States.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11400611 on ClinicalTrials.gov |
What this research studies
This project compares people from different racial and ethnic groups to see how common H. pylori infection, bacterial types, antibody responses, and stomach tissue changes are across groups. Investigators will use patient samples, lab tests, and existing clinical data to link those biological findings with past antibiotic use, body mass, and signs of atrophic gastritis. The team aims to find which factors drive the higher rates of gastric cancer in some populations and to point toward prevention strategies such as targeted H. pylori eradication. The work takes place at Duke and uses human samples and clinical records to connect lab results to real-world patient risk.
Who could benefit from this research
Good fit: Ideal participants are adults from racial or ethnic groups with higher gastric cancer rates, especially those with current or past H. pylori infection or relevant stomach symptoms or biopsy samples.
Not a fit: People without H. pylori infection, without available clinical or tissue samples, or whose concerns are unrelated to gastric cancer risk may not receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could guide better screening, prevention, and targeted H. pylori treatment for groups at higher risk of gastric cancer.
How similar studies have performed: Previous research shows that eradicating H. pylori lowers gastric cancer risk, but studies specifically explaining racial and ethnic differences in the US are limited.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EPPLEIN, MEIRA — DUKE UNIVERSITY
- Study coordinator: EPPLEIN, MEIRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections