Whole-body and organ aging clocks from blood proteomics during calorie restriction
Official title: Whole-Organism and Organ-Specific Biological Aging Clocks in Response to Calorie Restriction Interventions
Funded at Tulane University of Louisiana · NIH-11570631 · Data updated 2026-11-12
This project follows people in long-term calorie restriction studies to see how blood proteins reflect aging across the whole body and specific organs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $58,773 |
| NIH project number | 3R01AG094747-01S1 |
| Project ID | NIH-11570631 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults enrolled in or eligible for long-term calorie restriction trials with available blood samples and follow-up data.
✕Less likely to help
Individuals not participating in calorie restriction studies or without access to long-term follow-up data may not directly benefit.
What this research studies
Researchers will analyze blood samples from participants in established calorie restriction trials to identify proteomic aging clocks that correspond to overall aging and aging in specific organs. They will track changes in these clocks over time during the interventions and in follow-up years, and relate them to cardiometabolic outcomes such as blood pressure and metabolism. The study builds on previous trials to understand how calorie restriction may alter intrinsic aging processes at the molecular level using advanced proteomics. Insights could help tailor interventions to promote healthier aging and reduce age-related disease risk.
Why it matters
Potential benefit: If successful, the work could clarify how calorie restriction influences biological aging and guide personalized strategies to improve healthspan.
How similar studies have gone: Prior studies have identified proteome-based clocks and shown associations with aging, supporting potential success of this approach.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Qi, Lu — Tulane University of Louisiana
- Study coordinator: Qi, Lu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.