Virus‑linked cancers in people living with HIV
Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)
This program looks at how viruses like HPV and EBV affect cancer risk and outcomes in people living with HIV, especially in sub‑Saharan Africa.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11178705 on NIH RePORTER |
What this research studies
This partnership brings together cancer and infectious‑disease clinics and researchers to study tumors tied to HPV and EBV that affect people with HIV. They will collect clinical information and biological samples from people with HIV who have or are at risk for anal, cervical, oropharyngeal, penile, vulvar, and conjunctival tumors. Laboratory tests will map viral and immune features of those tumors to understand why these cancers are more common or harder to treat in people with HIV. The goal is to use those findings to guide better prevention, detection, and treatment approaches for people living with HIV.
Who could benefit from this research
Good fit: People living with HIV — particularly those in sub‑Saharan Africa or at partner sites — who have or are at risk for HPV‑related cancers or suspected EBV‑linked conjunctival tumors.
Not a fit: People without HIV or whose cancers are unrelated to HPV or EBV are unlikely to receive direct benefit from this program.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection, better prevention, and improved treatment outcomes for virus‑linked cancers in people living with HIV.
How similar studies have performed: Previous research has linked HPV and EBV to certain cancers and shown benefits from HPV vaccination and screening, but focused, large‑scale programs on virus‑associated cancers in people with HIV in sub‑Saharan Africa are relatively limited.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.