Virus-linked cancers in people living with HIV
Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)
This program looks at how viruses such as HPV and EBV affect cancer risk and treatment outcomes for people living with HIV, with a focus on sub-Saharan Africa.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11407890 on NIH RePORTER |
What this research studies
If you join this program, researchers at partnered clinics will collect medical information and blood and tumor samples from people living with HIV who have or are at risk for virus-linked cancers. They will test samples for HPV, EBV, and immune markers to map the viral and immune features of cancers such as anal, cervical, oropharyngeal, penile, vulvar, and conjunctival tumors. The work combines clinical data, laboratory analyses, and collaborations across sites in sub-Saharan Africa and the U.S. to address gaps in knowledge about cancers that disproportionately affect people with HIV. Findings aim to inform better prevention, earlier detection, and more effective treatment options for people living with HIV.
Who could benefit from this research
Good fit: Ideal participants are people living with HIV who have, or are at higher risk for, HPV- or EBV-related cancers and who receive care at participating clinics in sub-Saharan Africa or affiliated centers.
Not a fit: People without HIV or without virus-associated tumors, or those unable to access participating clinics, are unlikely to receive direct benefit from this program.
Why it matters
Potential benefit: If successful, this work could lead to improved prevention, earlier diagnosis, and more effective treatments for virus-associated cancers in people living with HIV.
How similar studies have performed: Prior research has clearly linked HPV and EBV to certain cancers and shown higher cancer risk in people with HIV, but coordinated studies of extra-cervical HPV cancers and suspected EBV-linked conjunctival tumors in sub-Saharan Africa are limited, making much of this work relatively novel.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.