VIOLIN 2.0: A vaccine knowledgebase to speed safe vaccines
Official title: VIOLIN 2.0: Vaccine Information and Ontology LInked kNowledgebase
Funded at University of Michigan at Ann Arbor · NIH-11550095 · Data updated 2026-11-12
A project to build VIOLIN 2.0, a user-friendly vaccine information and ontology knowledgebase to help researchers develop safer, more effective vaccines for diseases like HIV, TB, and malaria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 19, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $540,892 |
| NIH project number | 3U24AI171008-05S1 |
| Project ID | NIH-11550095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; this grant focuses on research infrastructure and knowledgebase development to support vaccine research.
✕Less likely to help
Direct patient participation is not required for this project.
What this research studies
If you or your loved ones are affected by infectious diseases, this project could help by organizing and linking vaccine information in a way that researchers can more quickly identify safe and effective vaccine candidates. The team plans to enhance data integration, interoperability, and analysis tools, building on VO and OAE foundations and using NLP methods to extract meaningful insights. The result could accelerate vaccine discovery and improve safety understanding, potentially speeding the path from idea to usable vaccines. The work is hosted at the University of Michigan, led by Yongqun He, and involves community input to maintain and grow a comprehensive knowledgebase.
Why it matters
Potential benefit: If successful, VIOLIN 2.0 could streamline vaccine research and safety assessment, potentially speeding the development of vaccines for HIV, tuberculosis, malaria, and other diseases.
How similar studies have gone: The project extends and updates an existing VIOLIN knowledgebase with strong preliminary data and established VO/OAE ontologies and vaccine design tools.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: He, Yongqun — University of Michigan at Ann Arbor
- Study coordinator: He, Yongqun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.