Using virus-specific immune cells to fight solid tumors
Therapeutically harnessing anti-viral resident memory T cells in solid tumors
This study is looking at how special immune cells that remember past viral infections can be used to help fight cancer by boosting the body’s ability to attack tumors, and it aims to create a new treatment that could improve outcomes for cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11210729 on NIH RePORTER |
What this research studies
This research investigates how resident memory T cells, which are specific to viral infections, can be utilized to enhance anti-tumor immunity in solid tumors. The approach involves reactivating these immune cells with viral peptides to overcome the immunosuppressive environment of tumors. By understanding the mechanisms of tumor cell killing and the role of viral specificity, the research aims to develop a novel immunotherapy that could improve treatment outcomes for cancer patients. The study will utilize both mouse models and human systems to explore these innovative therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who have a history of viral infections or are currently infected with the 2019 novel coronavirus.
Not a fit: Patients with tumors that do not involve viral infections or those who are not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy options that significantly improve cancer treatment outcomes.
How similar studies have performed: Other research has shown promise in leveraging immune cells for cancer treatment, suggesting that this approach could be a meaningful advancement in immunotherapy.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Rosato, Pamela — Dartmouth College
- Study coordinator: Rosato, Pamela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.