Using ultrasound to prevent infections after spinal surgery
Ultrasound-Triggered Prophylaxis as a Novel Paradigm for Preventing Spinal Infection
['FUNDING_OTHER'] · THOMAS JEFFERSON UNIVERSITY · NIH-10910042
This study is testing a new way to help prevent infections after spinal fusion surgery by using a special gel that releases antibiotics right where the surgery happens, making it easier for patients to heal and stay healthy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10910042 on ClinicalTrials.gov |
What this research studies
This research investigates a new method to prevent bacterial infections that can occur after spinal fusion surgery. It aims to develop an implantable hydrogel that releases antibiotics at the surgical site, both during and after surgery, to maintain effective antibiotic levels. The approach combines the use of traditional antibiotics with an innovative ultrasound-triggered release mechanism to enhance infection prevention. By targeting both Gram-positive and Gram-negative bacteria, this method seeks to reduce the risk of infection and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for spinal fusion surgery who are at risk of developing postoperative infections.
Not a fit: Patients who have already undergone spinal surgery without complications or those not undergoing spinal fusion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly lower the rates of infections following spinal surgeries, leading to better recovery and fewer complications for patients.
How similar studies have performed: Previous research has shown promise in using sustained-release antibiotic methods, but the specific ultrasound-triggered approach is relatively novel and untested.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DELANEY, LAUREN JO — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: DELANEY, LAUREN JO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections