Using tumor biology to improve breast cancer screening and prevention
Official title: Project 1: Implementing Risk-based Tools that Incorporate Tumor Biology to Optimize Screening and Prevention
Funded at University of California, San Francisco · NIH-10935789 · Data updated 2026-11-12
This study is looking at how to make breast cancer screenings better for women by tailoring them to individual risk factors, so women at higher risk of fast-growing cancers can get checked earlier and more often, while those at lower risk can have different preventive options.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 11, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $855,531 |
| NIH project number | 1P01CA281826-01A1 |
| Project ID | NIH-10935789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women with varying levels of breast cancer risk, particularly those identified as high-risk for specific cancer subtypes.
✕Less likely to help
Patients who do not have breast cancer risk factors or those who are not women may not receive benefit from this research.
What this research studies
This research focuses on personalizing breast cancer screening based on individual risk factors, particularly by analyzing tumor biology. It builds on the WISDOM Study, which compares personalized screening recommendations to the standard annual screening for all women. By identifying specific subtypes of breast cancer, the study aims to recommend earlier and more frequent screenings for women at high risk of fast-growing cancers, while offering different preventive measures for those at risk of slow-growing cancers. This approach seeks to optimize screening outcomes and reduce unnecessary procedures.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored breast cancer screening strategies, potentially improving early detection and reducing treatment-related morbidities.
How similar studies have gone: Previous studies, including the initial WISDOM Study, have shown promise in personalizing breast cancer screening based on individual risk factors, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Esserman, Laura J — University of California, San Francisco
- Study coordinator: Esserman, Laura J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.