Using topical treatments to improve healing of chronic wounds
Topical Senolytics for Chronic Wound Healing
['FUNDING_R03'] · MAYO CLINIC ROCHESTER · NIH-10725252
This study is looking at a new treatment to help older adults with chronic wounds, like those caused by diabetes, heal better by using special creams that target and remove stubborn cells that slow down healing.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10725252 on ClinicalTrials.gov |
What this research studies
This research investigates the use of topical senolytic agents to enhance the healing of chronic wounds, particularly in elderly patients suffering from conditions like diabetes. By targeting and eliminating senescent cells that hinder the healing process, the study aims to improve wound recovery outcomes. The researchers have developed prototype senolytic agents that have shown promise in laboratory settings, and they will further explore their effectiveness in a controlled clinical environment. The approach involves understanding the specific types of senescent cells present in chronic wounds and how they contribute to delayed healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals with chronic non-healing wounds, particularly those related to diabetes.
Not a fit: Patients with acute wounds or those not experiencing chronic wound issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic wounds, significantly improving healing times and quality of life for patients.
How similar studies have performed: While the concept of targeting senescent cells is relatively novel, preliminary studies have shown promise in similar approaches for improving wound healing.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WYLES, SARANYA PURUSHOTHAMAN — MAYO CLINIC ROCHESTER
- Study coordinator: WYLES, SARANYA PURUSHOTHAMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chronic Disease, chronic disorder, Diabetes Mellitus, diabetes, Disease