Using topical treatments to improve healing of chronic wounds
Official title: Topical Senolytics for Chronic Wound Healing
Funded at Mayo Clinic Rochester · NIH-10725252 · Data updated 2026-11-12
This study is looking at a new treatment to help older adults with chronic wounds, like those caused by diabetes, heal better by using special creams that target and remove stubborn cells that slow down healing.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 15, 2023 |
| Project end | August 14, 2026 |
| Funding year | 2023 |
| Award (this year) | $322,800 |
| NIH project number | 1R03AG082919-01 |
| Project ID | NIH-10725252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals with chronic non-healing wounds, particularly those related to diabetes.
✕Less likely to help
Patients with acute wounds or those not experiencing chronic wound issues may not benefit from this research.
What this research studies
This research investigates the use of topical senolytic agents to enhance the healing of chronic wounds, particularly in elderly patients suffering from conditions like diabetes. By targeting and eliminating senescent cells that hinder the healing process, the study aims to improve wound recovery outcomes. The researchers have developed prototype senolytic agents that have shown promise in laboratory settings, and they will further explore their effectiveness in a controlled clinical environment. The approach involves understanding the specific types of senescent cells present in chronic wounds and how they contribute to delayed healing.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic wounds, significantly improving healing times and quality of life for patients.
How similar studies have gone: While the concept of targeting senescent cells is relatively novel, preliminary studies have shown promise in similar approaches for improving wound healing.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Wyles, Saranya Purushothaman — Mayo Clinic Rochester
- Study coordinator: Wyles, Saranya Purushothaman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.