Using TNF receptors to reduce inflammation and promote bone healing in type 1 diabetes
Official title: Targeting TNF Receptors to Inhibit Inflammation and to Prompt Bone Regeneration in Type 1 Diabetes
Funded at Yale University · NIH-10886049 · Data updated 2026-11-12
This study is looking at how a special protein can help reduce inflammation and improve bone healing for people with type 1 diabetes, so if you have diabetes and are dealing with bone issues, this research might offer you new treatment options to help your recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 3, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $388,041 |
| NIH project number | 5R01AR076900-06 |
| Project ID | NIH-10886049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who experience delayed fracture healing.
✕Less likely to help
Patients without type 1 diabetes or those not experiencing issues with bone healing may not benefit from this research.
What this research studies
This research investigates how targeting TNF receptors can help reduce inflammation and enhance bone regeneration in patients with type 1 diabetes. The study focuses on a protein called progranulin, which has shown promise in promoting healing by interacting with specific receptors involved in bone formation. By exploring the effects of engineered proteins like Atsttrin, the research aims to find new treatments that can improve fracture healing in diabetic patients. Patients participating in this research may receive innovative therapies designed to address the unique challenges posed by diabetes-related bone issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve bone healing in patients with type 1 diabetes.
How similar studies have gone: Previous research has shown promise in targeting TNF receptors for treating autoimmune conditions, suggesting potential success for this novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Liu, Chuanju — Yale University
- Study coordinator: Liu, Chuanju
Related research
Other NIH-funded projects on the same topics.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
-
How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
-
Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.