Using the stomach's submucosa to deliver cell therapies for diabetes and other GI disorders
Official title: Leveraging the Gastric Submucosa as a Host for Cell Therapies
Funded at Brigham and Women's Hospital · NIH-10902920 · Data updated 2026-11-12
This study is looking at a new way to help people with type 1 diabetes and other gut issues by using a special technique to place helpful cells directly in the stomach, which could lead to better treatments and improved quality of life.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $83,932 |
| NIH project number | 1F32DK139701-01 |
| Project ID | NIH-10902920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 1 diabetes or degenerative gastrointestinal conditions who are seeking innovative treatment options.
✕Less likely to help
Patients with conditions unrelated to the gastrointestinal tract or those who do not have type 1 diabetes may not benefit from this research.
What this research studies
This research investigates how the submucosal layer of the gastrointestinal tract can be utilized as a site for implanting cell therapy devices. By employing endoscopic techniques, researchers aim to access this layer to potentially deliver therapeutic cells, such as pancreatic islets, directly to the stomach. The goal is to explore the effectiveness of this approach in treating conditions like type 1 diabetes and other degenerative gastrointestinal disorders. Patients may benefit from innovative treatments that could improve their quality of life and disease management.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for type 1 diabetes and other gastrointestinal disorders.
How similar studies have gone: While the approach of using the gastric submucosa for cell therapy is novel, similar techniques in other areas of regenerative medicine have shown promise.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Owyang, Stephanie Yuen — Brigham and Women's Hospital
- Study coordinator: Owyang, Stephanie Yuen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.