Using stem cell exosomes to help regenerate kidneys after injury.
Genome engineering of stem cells for kidney regeneration.
This study is exploring a new way to help veterans with acute kidney injury by using tiny particles called exosomes that come from special kidney cells, which might help heal and repair their damaged kidneys.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11063147 on NIH RePORTER |
What this research studies
This research focuses on developing a new treatment for acute kidney injury, particularly in veterans, by utilizing exosomes derived from induced nephron progenitor cells. These exosomes, which are small vesicles that carry beneficial molecules, may help repair damaged kidney cells and promote regeneration. The study involves isolating and characterizing these exosomes to understand their protective properties and how they can be effectively used in therapy. The ultimate goal is to translate these findings from laboratory research into practical treatments for patients suffering from kidney injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults, particularly veterans, who have experienced acute kidney injury.
Not a fit: Patients with chronic kidney disease or those who do not have acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve kidney recovery and function in patients with acute kidney injury.
How similar studies have performed: Other research has shown promising results using stem cell-derived exosomes for tissue regeneration, indicating potential success for this approach.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Woodard, Lauren Elizabeth — Veterans Health Administration
- Study coordinator: Woodard, Lauren Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.