Using special imaging techniques to detect bacterial infections in lung diseases
Official title: Siderophore based molecular imaging of pulmonary infections
Funded at University of Cincinnati · NIH-10878899 · Data updated 2026-11-12
This study is testing a new imaging method to help doctors better identify bacterial infections in people with COPD, so they can provide more effective treatments when symptoms worsen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $571,698 |
| NIH project number | 5R01HL168588-02 |
| Project ID | NIH-10878899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease who experience acute exacerbations potentially caused by bacterial infections.
✕Less likely to help
Patients without chronic obstructive pulmonary disease or those not experiencing acute exacerbations may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis of bacterial infections in patients with chronic obstructive pulmonary disease (COPD) by developing a new imaging method. The approach utilizes unique bacterial transporters and their metallophores as imaging agents to non-invasively identify live bacteria in the lungs. By distinguishing between bacterial and viral infections, this method aims to enhance treatment strategies for acute exacerbations of COPD. Patients will be monitored using advanced imaging technology to better understand their condition and tailor interventions accordingly.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses of bacterial infections in COPD patients, improving treatment outcomes.
How similar studies have gone: While the specific approach of using metallophores for imaging in this context is novel, similar imaging techniques have shown promise in other areas of infectious disease diagnosis.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Kotagiri, Nalinikanth — University of Cincinnati
- Study coordinator: Kotagiri, Nalinikanth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.