Using RNA patterns across cells and time to find new treatments for brain disorders
Applying RNA Logic in Space and Time to Neurologic Disease
This project develops new ways to read RNA inside different brain cells over time to reveal treatment targets for people with neurologic diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11325466 on NIH RePORTER |
What this research studies
Researchers will create and combine tools that map where and when RNA messages appear inside individual brain cells to reveal differences that matter for disease. The team emphasizes studying human biology alongside model systems so discoveries are validated in human tissue or samples. Work includes developing spatial and temporal RNA-profiling techniques, new cellular models, and analytic approaches to find hidden therapeutic targets. The overall aim is to translate basic RNA biology into leads that could eventually guide new therapies for neurologic disorders.
Who could benefit from this research
Good fit: People with neurologic diseases—especially those with genetic causes—or individuals willing to provide clinical samples or participate in related observational efforts would be most relevant to this work.
Not a fit: Patients seeking an immediate treatment are unlikely to benefit directly because this is early-stage, discovery-focused research that may take years to translate into therapies.
Why it matters
Potential benefit: If successful, this work could uncover new drug targets or biomarkers that lead to better treatments for people with brain disorders.
How similar studies have performed: Related spatial and single-cell RNA methods have yielded important biological insights, but this integrated focus on RNA logic across space and time as a route to therapies is largely novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Darnell, Robert B — Rockefeller University
- Study coordinator: Darnell, Robert B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.