Using redox balance to guide surgery and care for cartilage disease
Official title: Using redox balance to guide surgical and therapeutic decisions for cartilage disease
Funded at University of Wisconsin-Madison · NIH-11399719 · Data updated 2026-11-12
Aims to create smart surgical tools that use redox signals to guide treatment decisions for early cartilage damage and osteoarthritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $385,853 |
| NIH project number | 5R01AR083413-03 |
| Project ID | NIH-11399719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with early cartilage damage or osteoarthritis who are candidates for surgical or interventional procedures.
✕Less likely to help
Patients with late-stage OA or non-cartilage-related conditions may not benefit from this approach.
What this research studies
This project will develop optical redox imaging instruments that help surgeons see cartilage metabolism in real time during procedures. By measuring the balance of cellular oxidation and reduction, the tools aim to identify early cartilage changes and tailor therapeutic choices. The work combines imaging technology, metabolism science, and surgical practice to improve how OA is diagnosed and treated. If successful, these instruments could support earlier, more precise interventions and potentially slow disease progression.
Why it matters
Potential benefit: Patients with early cartilage damage or OA could receive more personalized and timely treatment guided by real-time metabolic information.
How similar studies have gone: ORI has shown promise in cancer research for guiding treatments, suggesting potential but this specific cartilage application is being tested.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Henak, Corinne R — University of Wisconsin-Madison
- Study coordinator: Henak, Corinne R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.