Using probiotics to control graft-versus-host disease
Control of GVHD by Probiotics with individual Commensal Bacteria
This study is looking at how certain probiotics might help people with graft-versus-host disease (GVHD) after a stem cell transplant by improving gut health and boosting their immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11083695 on NIH RePORTER |
What this research studies
This research investigates how specific probiotics can help manage graft-versus-host disease (GVHD) in patients who have undergone allogeneic hematopoietic cell transplantation. The study focuses on the role of the gut microbiota in influencing immune responses and aims to identify safe and effective live microorganisms that can improve health outcomes for these patients. By exploring various interventional strategies, including probiotics, the research seeks to enhance the diversity of gut bacteria and mitigate the adverse effects of GVHD. Patients may be monitored for changes in their gut microbiota and overall health as part of the treatment approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have received an allogeneic bone marrow transplant and are at risk for developing graft-versus-host disease.
Not a fit: Patients who have not undergone allogeneic hematopoietic cell transplantation or those with pre-existing severe gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of GVHD, reducing complications and enhancing recovery for transplant patients.
How similar studies have performed: Previous studies have shown promise in using probiotics and microbiota manipulation to improve outcomes in similar patient populations, indicating a potential for success in this approach.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Yu, Xue-Zhong — Medical College of Wisconsin
- Study coordinator: Yu, Xue-Zhong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.