Using polymers to improve treatments for cholera and male infertility
Polymer Approaches to Receptor Activation and Inhibition
This study is looking at how special materials called polymers can help fight cholera and improve male fertility by either blocking harmful toxins or boosting sperm function, with the goal of creating new treatments you can take by mouth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11092876 on NIH RePORTER |
What this research studies
This research investigates how functionalized polymers can be used to either activate or inhibit biological receptors, focusing on cholera and male infertility. The team aims to develop oral therapeutics that can prevent the spread of cholera by blocking the binding of the cholera toxin to cells. Additionally, the research explores the use of glycopolymers to enhance sperm function, specifically targeting the acrosomal exocytosis process that is crucial for male fertility. By synthesizing different polymer systems and analyzing their effects, the researchers hope to create effective diagnostic tools and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of cholera infection and American males aged 15-44 experiencing infertility or subfertility.
Not a fit: Patients who are not at risk for cholera or who do not have issues related to male infertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new oral therapies for cholera and improved diagnostics and treatments for male infertility.
How similar studies have performed: Previous research has shown promise in using polymers for similar applications, indicating potential for success in this novel approach.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sampson, Nicole S — University of Rochester
- Study coordinator: Sampson, Nicole S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.