Using platelet-mitochondria to treat kidney injury
Platelet-mitochondria transplantation to treat mitochondrial dysfunction in acute kidney injury
['FUNDING_R01'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11085302
This study is looking at a new way to help people with acute kidney injury by using platelets to deliver tiny energy factories called mitochondria directly to the damaged kidney cells, with the hope of preventing the injury from getting worse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11085302 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to treat acute kidney injury (AKI) by using platelets to deliver mitochondria directly to damaged kidney cells. The principal investigator, with expertise in platelet structure, collaborates with specialists in kidney disease and mitochondrial function to explore this innovative therapy. The goal is to halt the progression of AKI to more severe conditions like end-stage renal disease, which currently has no effective pharmacological treatments. By focusing on the cellular mechanisms involved in kidney injury, this research aims to provide a new therapeutic strategy for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients who are experiencing acute kidney injury.
Not a fit: Patients with chronic kidney disease or those who are not currently hospitalized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve kidney function recovery and reduce the risk of progression to chronic kidney disease in patients with acute kidney injury.
How similar studies have performed: While the approach of using mitochondria transplantation is innovative, similar strategies in other contexts have shown promise, suggesting potential for success in this area as well.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOUCHAREB, RIHAB — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: BOUCHAREB, RIHAB
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury, Breast Cancer