Using nanoparticles to reduce inflammation after trauma
Nanoparticle-mediated reprogramming of circulating monocytes and neutrophils to decrease inflammation-mediated damage after trauma
This study is looking at tiny particles that can help change how certain immune cells in your blood work after an injury, with the hope of reducing harmful inflammation and helping your body heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10669080 on NIH RePORTER |
What this research studies
This research focuses on developing nanoparticles that can change the behavior of certain immune cells, specifically monocytes and neutrophils, in the blood following trauma. By reprogramming these cells, the goal is to decrease harmful inflammation that can hinder tissue regeneration and lead to further damage. The nanoparticles are designed to be delivered in a minimally invasive way, targeting the immune cells to alter their function and promote a healing environment. This approach aims to improve recovery outcomes by reducing inflammation and enhancing tissue repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced trauma and are suffering from inflammation-related complications.
Not a fit: Patients with chronic inflammatory conditions unrelated to trauma may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery from traumatic injuries by minimizing inflammation and promoting tissue regeneration.
How similar studies have performed: Previous research has shown promise in using nanoparticles for immune modulation, indicating potential success for this novel approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shea, Lonnie D — University of Michigan at Ann Arbor
- Study coordinator: Shea, Lonnie D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.