Using nanoparticles to promote transplant tolerance in the immune system
Core B
['FUNDING_P01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10868757
This study is exploring a new way to help people who need organ transplants by using tiny particles and special cells to help the body accept the new organ without fighting it off, making the process easier and safer for patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10868757 on ClinicalTrials.gov |
What this research studies
This research focuses on developing antibody-coated nanoparticles and specialized cells to alter the environment of lymph nodes, encouraging the body to accept transplanted organs without rejection. By reprogramming the immune response, the project aims to create a more tolerant state that could benefit patients undergoing transplants. The approach involves synthesizing and characterizing these nanoparticles and cells to ensure they effectively target lymph nodes and promote immune tolerance. This innovative method represents a significant shift from traditional transplant tolerance strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are scheduled for organ transplants and may benefit from enhanced immune tolerance.
Not a fit: Patients who are not undergoing transplantation or those with conditions unrelated to immune tolerance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved transplant outcomes and reduced rejection rates for patients receiving organ transplants.
How similar studies have performed: While the approach of using nanoparticles for immune modulation is gaining traction, this specific method targeting lymph nodes for transplant tolerance is novel and has not been extensively tested in prior studies.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABDI, REZA — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ABDI, REZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases