Using N-Oxides to create new pain relief and mental health medications
Official title: Application of N-Oxides for the Synthesis of Nitrogen Heterocycles
Funded at Duquesne University · NIH-10579651 · Data updated 2026-11-12
This study is exploring new ways to create important ingredients for medicines that help with cancer and mental health issues, using a special chemical process to make it easier to develop better treatments for pain and psychiatric conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duquesne University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 16, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $406,457 |
| NIH project number | 1R15GM148917-01 |
| Project ID | NIH-10579651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain or psychiatric disorders who may benefit from new treatment options.
✕Less likely to help
Patients who are not experiencing pain or mental health issues may not receive any benefit from this research.
What this research studies
This research focuses on developing new nitrogen heterocycles, which are important components in many effective medications for conditions like cancer and mental health disorders. The team will utilize N-oxides as starting materials to create these compounds through a specific chemical reaction known as [3+2] cycloaddition. By improving the understanding of how these reactions work, the researchers aim to overcome previous challenges in synthesizing these valuable compounds, potentially leading to more effective treatments. This innovative approach could streamline the development of new drugs that target pain relief and psychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective medications for pain management and mental health disorders.
How similar studies have gone: While the use of N-oxides in drug synthesis has been explored previously, this research aims to apply a novel mechanistic understanding that could lead to significant advancements in the field.
Where this research is happening
-
Duquesne University
Pittsburgh, United States Active
Researchers
- Principal investigator: Montgomery, Thomas — Duquesne University
- Study coordinator: Montgomery, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.